Effects of Topical Carrageenan and Vitamin D on Oral Tumor in Rats

DMBA is a carcinogenic chemical substance that used experimentally to induce a variety of tumors in an attempt to study the pathogenesis of tumor and to assess the chemotherapeutic agents. Experimentally, several studies showed the effectiveness of many substances in reducing or attenuating the effects of DMBA-induced tumorogenesis by improving the antioxidant status, augmenting the apoptosis, inducing antiproliferative, and activation of cytotoxic T cell-dependent tumor regression. -carrageenan is a food stabilizer agent which has an antiproliferative effect, while vitamin D is a pro-hormone acts on the nuclear receptor and has a cytotoxic effect against cancer. There are several biomarkers that contribute or related to the oral cancer . In human, the vitamin D reduces the risk of cancers and maintains high serum levels of vitamin D in cancer-patients which improve the survival rate. The rational of the study is both -carrageenan and vitamin D have pleiotropic effects including anticancer through different mechanisms, and application of these substances via different routes can attenuate the oral cancer induced by DMBA