Fundamentals and Applications of Immunoadsorption
(Sprache: Englisch)
The term immunoadsorption refers to a process that removes immunologically relevant factors from the patients' plasma by means of extracorporeal circulation utilizing adsorptive binding forces. This textbook provides an overview on the current knowledge of...
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The term immunoadsorption refers to a process that removes immunologically relevant factors from the patients' plasma by means of extracorporeal circulation utilizing adsorptive binding forces. This textbook provides an overview on the current knowledge of immunoadsorption treatment in selected clinical conditions.
Following a basic chapter on terminology and the description of various immunoadsorption techniques, major clinical indications for this technique are discussed in detail by expert groups. The rationale for utilizing immunoadsorption treatment is explained according to new insights in pathophysiology.
Apheresis treatment requires a close interdisciplinary collaboration. In this sense, internationally acknowledged experts from various subspecialties have contributed to this monograph, thereby addressing medical doctors from a wide variety of fields.
Inhaltsverzeichnis zu „Fundamentals and Applications of Immunoadsorption “
Contents1. Immunoadsorption Devices and Technique 141.1. References 162. Extracorporeal Therapy in Rheumatoid Arthritis 182.1. References 213. Hemophilia 243.1. Hemophilia A and B 243.1.1. Disease characteristics 243.1.2. Treatment 243.1.3. Treatment complications and inhibitor development 243.1.4. Laboratory tests 243.1.5. Conventional inhibitor treatment: immunotolerance treatment 253.1.6. The relevance of immunoadsorption in inhibitor treatment 253.2. Acquired Hemophilia (AH) 253.2.1. Disease characteristics 253.2.2. Laboratory tests 263.2.3. Immunological background 263.2.4. Conventional treatment 273.2.5. Immunoadsorption in Acquired Hemophilia 273.2.6. Cost benefit analysis of IA in hemophilia 293.2.7. Future aspects and improvements 293.3. References 294. Immunoadsorption Treatment for Autoimmune Bullous Diseases 324.1. Immunoadsorption in pemphigus 324.2. Immunoadsorption in pemphigoid diseases and epidermolysis bullosa acquisita 384.2.1. Adverse events 394.3. Recommendations 394.3.1. (Contra-) indications 394.3.2. Treatment protocol 394.4. Conclusions 394.5. References 405. Immunoadsorption for Neurological Diseases 445.1. Immunological basis and rationale for immunoadsorption 445.2. Clinical applications 445.2.1. Autoimmune disorders of the neuromuscular junction 445.2.2. Disorders of peripheral nerves 465.2.3. Disorders of the central nervous system 465.3. Future research 475.4. References 476. Immunoadsorption for Dilated Cardiomyopathy - Clinical Results 506.1. Disturbances of the immune system in patients with dilated cardiomyopathy 506.2. Clinical studies for immunoadsorption in dilated cardiomyopathy 506.3. Mechanisms of immunoadsorption in dilated cardiomyopathy 516.4. Summary 536.5. References 537. ABO-Incompatible Organ Transplantation 567.1. ABO-incompatible kidney transplantation 567.1.1. ABO expression in the kidney 577.1.2. Technique to determine ABO-incompatible titer 577.1.3. Techniques and protocol for ABO-incompatible kidney
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transplantation 577.1.4. Transfusion after ABO-incompatible kidney transplantation 597.1.5. Kidney biopsy after ABO-incompatible transplantation 597.1.6. Outcome after ABO-incompatible kidney transplantation 607.2. ABO-incompatible liver transplantation 607.3. ABO-incompatible heart and lung transplantation 617.4. Outlook 627.5. References 628. Antibody-Mediated Rejection in Kidney Transplantation 668.1. The concept of alloantibody-mediated rejection 668.1.1. AMR types 668.1.2. C4d and the critical role of complement 678.2. Diagnosis of antibody-mediated rejection (AMR) 678.2.1. The diagnostic value of renal allograft biopsy 678.2.2. Diagnostic criteria for acute AMR 678.2.3. Diagnostic criteria for chronic AMR 698.3. Frequency and natural course of acute AMR 698.4. Treatment of acute AMR - general remarks 718.5. Immunoadsorption in the treatment of acute AMR 728.5.1. Uncontrolled series 728.5.2. Results of a randomized controlled trial 738.6. Plasmapheresis-based protocols 748.7. Treatment of chronic AMR 758.8. References 759. Immunoadsorption for the Adjunctive Treatment of Sepsis 789.1. Immunological Basics 789.1.1. The immunopathophysiology of sepsis 789.1.2. Adsorption in sepsis: technical considerations 809.2. Clinical Applications 809.2.1. Non-selective and semi-selective adsorption in sepsis 829.2.2. Highly selective adsorption in sepsis 839.3. Conclusion 849.4. References 8410. From Immunoadsorption to Bioreactor Therapy - Granulocyte-Based Treatment of Sepsis 8810.1. Rationale and technical concept 8810.2. In-vitro studies 8910.3. Animal experiments 9010.4. Clinical study 9110.5. Discussion 9210.6. Conclusions 9310.7. References 93Index 95
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Bibliographische Angaben
- 2009, 95 Seiten, Maße: 17,4 x 24,6 cm, Gebunden, Englisch
- Herausgegeben: Norbert Braun
- Verlag: UNI-MED VERLAG AG
- ISBN-10: 383741163X
- ISBN-13: 9783837411638
Sprache:
Englisch
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