Inorganic Biochemistry of Iron Metabolism

Preface. 1. Solution Chemistry of Iron in Biological Media. 1.1 Aqueous Solution Chemistry of Iron. 1.2 Biomineralisation. References. 2. The Importance of Iron for Biological Systems. 2.1 Introduction. 2.2 Physical Techniques for the Study of Iron in Biological Systems. 2.3 Haemoproteins. 2.4 Iron Sulfur Proteins. 2.5 Other Iron Containing Proteins. 3. Microbial Iron Transport and Metabolism. 3.1 Introduction. 3.2 Siderophores. 3.3 Intracellular Iron Metabolism. 3.4 Control of Gene Expression by Iron. 4. Iron Uptake by Plants and Fungi. 4.1 Iron Acquisition by Plants. 4.2 Iron Acquisition by Yeast. References. 5. Cellular Iron Uptake and Export in Mammals. 5.1 The Transferrins. 5.2 Structure of Transferrins. 5.3 Transferrin Iron Binding and Release. 5.4 Iron Uptake by Mammalian Cells Uptake of Transferrin Bound Iron. 5.5 Cellular Iron Uptake and Export. 5.6 Uptake of Iron from Other Sources than Transferrin. 5.7 Nontransferrin Bound Iron. 5.8 Ferritin Bound Iron. 5.9 Haptoglobin and Haemopexin as Iron Transporters. References. 6. Intracellular Iron Storage and Biomineralisation. 6.1 Intracellular Iron Storage. 6.2 Biomineralisation. 7. Intracellular Iron Metabolism and Cellular Iron Homeostasis. 7.1 Intracellular Iron Metabolism. 7.2 Cellular Iron Homeostasis. References. 8. Iron Absorption in Mammals, with Particular Reference to Man, and Regulation of Systemic Iron Balance. 8.1 Iron Metabolism in Man: An Overview. 8.2 Sources of Dietary Iron in Man and the Importance of Luminal Factors. 8.3 Iron Losses and Requirements for Absorbed Iron. 8.4 Molecular Mechanisms of Mucosal Iron Absorption. 8.5 Regulation of Iron Uptake by the Enterocyte. 8.6 Regulation of Systemic Iron Balance. References. 9. Pathophysiology of Iron Deficiency and Iron Overload in Man. 9.1 Introduction: Acquired and Genetic Disorders of Iron Metabolism. 9.2 Homeostatic Control of the Internal Milieu and Consequences of Its Disruption. 9.3 Iron Overload Syndromes. 9.4 Primary Iron Overload,