Medical Biochemistry at a Glance

Preface to the third edition 7
 
Acknowledgements to the third edition 7
 
Figure key 8
 
SI/mass unit conversions 9
 
Part 1 Acids, bases and pH
 
1 Acids, bases and hydrogen ions (protons) 10
 
2 Understanding pH 12
 
3 Production and removal of protons into and from the blood 14
 
4 Metabolic alkalosis and metabolic acidosis 16
 
5 Respiratory alkalosis and respiratory acidosis 18
 
Part 2 Structure of amino acids and proteins
 
6 Amino acids and the primary structure of proteins 20
 
7 Secondary structure of proteins 22
 
8 Tertiary and quaternary structure and collagen 24
 
Part 3 Formation of ATP: oxidation and reduction reactions
 
9 Oxidation/reduction reactions, coenzymes and prosthetic groups 26
 
10 Anaerobic production of ATP by substrate-level phosphorylation, from phosphocreatine and by the adenylate kinase (myokinase) reaction 28
 
11 Aerobic production of ATP 30
 
12 Biosynthesis of ATP by oxidative phosphorylation I 32
 
13 Biosynthesis of ATP by oxidative phosphorylation II 34
 
14 What happens when protons or electrons leak from the respiratory chain? 36
 
15 Free radicals, reactive oxygen species and oxidative damage 38
 
16 Aerobic oxidation of glucose to provide energy as ATP 40
 
17 Anaerobic oxidation of glucose by glycolysis to form ATP and lactate 42
 
18 Anaerobic glycolysis in red blood cells, 2,3-BPG (2,3-DPG) and the Bohr effect 44
 
Part 4 Carbohydrates
 
19 Carbohydrates 46
 
20 Absorption of carbohydrates and metabolism of galactose 48
 
21 Fate of glucose in liver: glycogenesis and lipogenesis 50
 
22 Fructose metabolism 52
 
23 Glucose homeostasis 54
 
24 Glucose-stimulated secretion of insulin from ²-cells 56
 
25 Regulation of glycogen metabolism 58
 
26 Glycogen breakdown (glycogenolysis) and glycogen

"It will also be essential reading for those preparing for professional qualifications such as FIBMS and FRCPath, possibly even MRCP, and will serve as an excellent resources for the more senior researcher, lecturer and academic." ( The Bulletin of The Royal College of Pathologists , 1 January 2013) "It will also be essential reading for those preparing for professional qualifications such as FIBMS and FRCPath, possibly even MRCP, and will serve as an excellent resources for the more senior researcher, lecturer and academic." ( The Bulletin of The Royal College of Pathologists , 1 January 2013) Clinical Pathology for the Veterinary Team will help experienced veterinary technicians set up various clinical laboratory diagnostic tests. It provides a good explanation of basic laboratory practices, the underlying concepts of many laboratory tests, and the physiology of common disease conditions. This book is well worth the price. (Journal of the American Veterinary Medical Association, December 2010) This book provides a good overall summary of basic clinical pathology in small animals. Although it is fairly short and concise, it contains all the necessary relevant information and includes a CD that takes readers thorough six complicated cases, step by step. This is a useful book that would be a handy reference to have in a practice. It is easy to read, concise, and informative. Although it is aimed at small animal veterinary teams, it includes limited information about large animal species, which is important for a good, general understanding. (Doodys, December 2010) Clinical Pathology for the Veterinary Team offers a fine recourse for technical team members involved in clinical diagnostic evaluation. Machinery calibration, normal anatomy, clinical diagnostics and more are revealed in chapters that provide key technical information for Obtaining and evaluating samples, surveying the disease process, the progress of identification and treatment, and including a DVD with

I have taught biochemistry to medical students and to undergraduates and graduate students, at both Temple University School of Medicine and at Case Western Reserve University, since 1968, so that I have had a great deal of experience in the field and have a feel for what works well for medical students.
Medical Biochemistry at a Glance would be an excellent book for USMLE Step 1. In my experience, medical students (and pre-medical students) would greatly benefit from reading it in preparation for the exam.
This compares very well with Lippincott's Biochemistry - this has the right price and approach to compete with Lippincott for a less expensive and more accessible alternative to the larger text books that are out there.
I like the way it combines the metabolic pathways and principles in such a creative fashion, and the metabolism sections are among the best I have read and the easiest to understand. Metabolism is a very complicated subject and, in my experience, most teachers of the subject would really benefit from your text. (Richard W. Hanson, Case Western Reserve University School of Medicine)