Preparative Chromatography

Preface

INTRODUCTION
On the Development of Chromatography
Focus of the Book
Recommendation to read this Book

FUNDAMENTALS AND GENERAL TERMINOLOGY
Principles of Adsorption Chromatography
Basic Effects and Chromatographic Definitions
Fluid Dynamics
Mass Transfer Phenomena
Equilibrium Thermodynamics
Thermodynamic Effects on Mass Separation

STATIONARY PHASES AND CHROMATOGRAPHIC SYSTEMS
Column Packings
Selection of Chromatographic Systems

CHROMATOGRAPHY EQUIPMENT: ENGINEERING AND OPERATION
Introduction
Engineering and Operational Challenges
Chromatography Columns Market
Chromatography Systems Market
Process Control
Packing Methods
Process Troubleshooting
Disposable Technology for Bio-Separations

PROCESS CONCEPTS
Discontinuous Processes
Continuous Processes
Choice of Process Concepts

MODELING AND MODEL PARAMETERS
Introduction
Models for Single Chromatographic Columns
Modeling HPLC plants
Calculations Methods
Parameter Determination
Experimental Validation of Column Models

MODEL BASED DESIGN, OPTIMIZATION AND CONTROL
Basic Principles and Definitions
Batch Chromatography
Recycling Chromatography
Conventional Isocratic SMB Chromatography
Isocratic SMB Chromatography under Variable Operating Parameters
Gradient SMB Chromatography
Multicolumn Systems for Bioseparations
Chromatographic SMB Reactors
Advanced Process Control

APPENDIX B
Data of Test Systems

Professor Schmidt-Traub was Professor for Plant and Process Design at the Department of Biochemical and Chemical Engineering, University of Dortmund, Germany until his retirement in 2006. He is still active in the research community and his main areas of research focus on preparative chromatography, down stream processing, integrated processes, plant design and innovative energy transfer. Prior to his academic appointment, Prof. Schmidt-Traub gained 15 years of industrial experience in plant engineering. Prof. Seidel-Morgenstern is the Director of the Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany and holds the Chair in Chemical Process Engineering at the Otto-von-Guericke-Universität, Magdeburg, Germany. He received his Ph.D. in 1987 at the Institute of Physical Chemistry of the Academy of Sciences in Berlin. From there he went on to work as postdoctoral fellow at the University of Tennessee, Knoxville, USA. In 1994 he finished his habilitation at the Technical University in Berlin. His research is focused on New Reactor Concepts, Chromatographic Reactors, Membrane Reactors, Adsorption and Preparative Chromatography and Separation of Enantiomers amongst others. Dr. Michael Schulte is Senior Director Emerging Businesses Energy at Merck KGaA Performance Materials, Darmstadt, Germany. In his Ph.D. thesis at the University of Münster, Germany he developed new chiral stationary phases for chromatographic enantioseparations. In 1995 he joined Merck and has since then been responsible for research and development in the area of preparative chromatography, including the development of new stationary phases, new separation processes and the implementation of Simulated Moving Bed-technology at Merck. In his current position one of his areas of research is the use of Ionic Liquids for separation processes.

"Das Buch beginnt mit der Frage: Warum ein weiteres Buch zum Thema "Präparativer Chromatographie"... Für alle, die das Buch gelesen haben, wird sich diese Frage nicht mehr stellen. Es war absolut überfällig in einer Welt, in der wir langsam die Komplexität natürlicher Prozesse begreifen und die Überschreitung der Grenzen zwischen Chemie, Physik, den Ingenieurswissenschaften und weiteren Disziplinen zwingend notwendig wird."
Nachrichten aus der Chemie"...es gibt kein vergleichbares Werk. Für Pharmazeuten ist es besonders im Kontext der Herstellung, Reinigung und Isolierung von Wirkstoffen und Verunreinigungen außerordentlich nützlich."
Pharmazie in unserer Zeit

"I would not hesitate to recommend it to anyone working in this field."
Chromatographia

"Overall the coverage is a bit uneven - nevertheless the volume does compile some useful material... In conclusion, this is a comprehensive reference text, which should find its way into the libraries of all companies who are serious about process scale preparative chromatography, whether internally or via outsource contracts."
Organic Process Research and Development

"This special volume is essential for chemists and engineers working in chemical and pharmaceutical industries, as well as for food technologies, due to the interdisciplinary nature of these preparative chromatographic processes."
Advances in Food Sciences