The Calabar Bean and its Alkaloids
From Magic, Via Miracle, to Memory
(Sprache: Englisch)
Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of...
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Klappentext zu „The Calabar Bean and its Alkaloids “
Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a "lead compound") have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial.
Inhaltsverzeichnis zu „The Calabar Bean and its Alkaloids “
Chronology.- Abbreviations.- Preface and acknowledgements.- 1. Introduction.- 2. l-Physostigmine (eserine).- 2.1. Natural occurrence.- 2.2. Structure elucidation.- 2.3. Synthesis of:- 2.3.1. by early approaches, including the first to be successful.- 2.3.2. l-physostigmine and the 3a-alkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole ring system.- 2.3.3. d-physostigmine.- 2.4. Absolute configuration, together with that of the other structurally-established alkaloids of the Calabar bean.- 2.5. Biogenesis.- 2.6. Ultraviolet absorption spectrum and reaction in an acidic medium.- 2.7. Mass spectrum.- 2.8. Detection, assay and instability.- 2.8.1. Qualitative and quantitative analysis.- 2.8.2. Rubreserine.- 2.8.3. Eserine blue.- 2.8.4. Eserine brown.- 3. l-Physovenine.- 3.1. Isolation and structure elucidation.- 3.2. Synthesis of the:- 3.2.1. racemate.- 3.2.2. l
Bibliographische Angaben
- Autor: Brian Robinson
- 2023, 1st ed., 267 Seiten, Maße: 15,5 x 23,5 cm, Gebunden, Englisch
- Verlag: Springer Netherlands
- ISBN-10: 9402411909
- ISBN-13: 9789402411904
- Erscheinungsdatum: 19.07.2019
Sprache:
Englisch
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