Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience (ePub)
Volume 2: Microdialysis and Sensing of Neural Tissues
(Sprache: Englisch)
Volume 1 of this series focused mainly on small molecules which are intrinsically electroactive. Volume 2 continues to provide current approaches to real time measurements of essential species in the central nervous system. It describes microdialysis, a...
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Volume 1 of this series focused mainly on small molecules which are intrinsically electroactive. Volume 2 continues to provide current approaches to real time measurements of essential species in the central nervous system. It describes microdialysis, a sampling technique, which facilitates the removal of small volumes of solution containing the analyte(s) of interest which can be subsequently separated by chromatography and analyzed by a range of techniques. These include electrochemistry, UV-Vis spectroscopy, fluorescence and mass spectroscopy. This approach affords the opportunity to measure a range of targets in real-time thus providing access to pharmacokinetic/pharmacodynamics measurements affording the possibility of measuring the disappearance of a drug after administration and the subsequent appearance of metabolites. Microdialysis further affords the ability to sample peptides and proteins of neurobiological interest.Consistent with the goals of Volume 1, Volume 2 seeks to provide for scientists in the field of neurobiology a base of bioanalytical techniques that may not be familiar to them. Specific examples are provided and the fundamental basis of the technique is also covered.
Bibliographische Angaben
- 2017, Englisch
- Herausgegeben: Adrian C Michael, George S Wilson
- ISBN-10: 9813220546
- ISBN-13: 9789813220546
- Erscheinungsdatum: 28.06.2017
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- Dateiformat: ePub
- Größe: 11 MB
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Sprache:
Englisch
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