Fundamental Neuropathology for Pathologists and Toxicologists (PDF)

Editors' Preface. Forward. Acknowledgments. Part I. Fundamentals of Neurobiology. Chapter 1. Fundamentals of Toxicologic Neuropathology: An Introduction. Chapter 2. Functional Neuroanatomy. Chapter 3. Atlas of Comparative Neuroanatomy. Chapter 4. Principles of Comparative and Correlative Neurodevelopment, and their Implications for Developmental Neurotoxicity. Chapter 5. Localizing Neuropathologic Lesions Using Neurologic Findings. Chapter 6. Behavioral Model Systems for Evaluating Neuropathology. Chapter 7. Cognitive Assessments in Non-Human Primates. Chapter 8. The Impact of Aging on Brain Structure and Function in Rodents and Canines. Chapter 9. Fundamentals of Neurotoxicity Detection. Part 2. Toxicologic Neuropathology: Methodology. Chapter 10. Practical Neuropathology of the Rat and Other Species. Chapter 11. The Fluoro-Jade Dyes: Novel, Sensitive, and Reliable Fluorochromes for the Histochemical Localization of Degenerating Neurons. Chapter 12. Histologic Markers of Neurotoxicity (Nonfluorenscence). Chapter 13. Common Histologic Artifacts in Nervous System Tissues. Chapter 14. High-Definition Microscopic Analysis of the Nervous System. Chapter 15. Stereological Solutions for Common Quantitative Endpoints in Neurotoxicity. Chapter 16. Anatomy and Processing of Peripheral Nerve Tissues. Chapter 17. Pathology Methods in Non-clinical Neurotoxicity Studies: Evaluation of Muscle. Chapter 18. In Vivo Imaging Applications for the Nervous System in Animal Models. Chapter 19. Cerebrospinal Fluid Analysis in Toxicologic Neuropathology. Chapter 20. Molecular Techniques in Toxicologic Neuropathology. Part 3. Toxicologic Neuropathology: Current Practices. Chapter 21. Evaluation of the Adult Nervous System in Preclinical Studies. Chapter 22. Pathology Methods in Non-clinical Neurotoxicity Studies: Developing Central Nervous System. Chapter 23. Neuropathology Analysis of the Peripheral Nervous System. Chapter 24. Toxicologic Pathology of the Retina and Optic Nerve. Chapter

BRAD BOLON, DVM, MS, PhD, Diplomate ACVP, Diplomate ABT, Fellow
ATS, Fellow IATP, has spent over twenty years as a practitioner
and teacher of toxicologic neuropathology. He is the founder of
GEMpath, Inc., an experimental pathology consultancy specializing
in drug discovery research.

MARK T. BUTT, DVM, Diplomate ACVP, is the founder of Tox
Path Specialists, LLC, a company that provides neuropathology and
histology support to pharmaceutical and biotechnology firms
developing novel therapies that target nervous system diseases. He
has over twenty years' experience providing neuropathology support
and has evaluated over four hundred studies supporting regulatory
submissions for neuroactive compounds.

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