Inorganic Chemical Biology (ePub)

Understanding, identifying and influencing the biological
systems are the primary objectives of

chemical biology. From this perspective, metal complexes have
always been of great assistance

to chemical biologists, for example, in structural identification
and purification of essential

biomolecules, for visualizing cellular organelles or to inhibit
specific enzymes. This inorganic side

of chemical biology, which continues to receive considerable
attention, is referred to as inorganic

chemical biology.

Inorganic Chemical Biology: Principles, Techniques and
Applications provides a comprehensive

overview of the current and emerging role of metal complexes in
chemical biology. Throughout all

of the chapters there is a strong emphasis on fundamental
theoretical chemistry and experiments

that have been carried out in living cells or organisms. Outlooks
for the future applications of

metal complexes in chemical biology are also discussed.

Topics covered include:

* Metal complexes as tools for structural biology

* IMAC, AAS, XRF and MS as detection techniques for metals in
chemical biology

* Cell and organism imaging and probing DNA using metal and
metal carbonyl complexes

* Detection of metal ions, anions and small molecules using
metal complexes

* Photo-release of metal ions in living cells

* Metal complexes as enzyme inhibitors and catalysts in
living cells

Written by a team of international experts, Inorganic Chemical
Biology: Principles, Techniques and

Applications is a must-have for bioinorganic,
bioorganometallic and medicinal chemists as well as

chemical biologists working in both academia and industry.