Neural Degeneration and Repair
Expression Profiling, Proteomics, Glycomics and Systems Biology
(Sprache: Englisch)
With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and...
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Klappentext zu „Neural Degeneration and Repair “
With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases.Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation etc. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists.
Der Titel beschreibt Anwendungsmglichkeiten der so genannten "...omics" mit dem Ziel, destruktive Vorgnge innerhalb des Nervensystems besser zu verstehen und damit neue diagnostische und therapeutische Wege fr die Behandlung der schwerwiegenden neuralen Erkrankungen aufzuzeigen.
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With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases.
Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation etc. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists.
----------------------------------------
With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases.
Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation etc. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists.
Inhaltsverzeichnis zu „Neural Degeneration and Repair “
1. INTRODUCTIONMicroarrays in Translational Neuroscience - from Laboratory to Clinical Applications2. REACTIONS OF PERIPHERAL NERVE TO TRAUMATIC INJURY AND AXON REGENERATIONThe Potential of Genomewide Expression Profiling in Models of Peripheral Nervous System Injury and RepairLargescale Screening for Regeneration-Associated Neural Proteins and GenesPatterns of Genetic Regulation and Target Remodelling in Response to Molecular Signals to NeuronsMicroarray Analysis to Decipher Peripheral Nerve MyelinationUnravelling the Mechanism of Neuropathic Pain using cDNA ArraysComparison of Axotomy-induced Neuronal Gene Expression Profiles in Regenerating Peripheral Nerve and Non-regenerating CNS Fiber Tract3. CENTRAL NERVOUS SYSTEM TRAUMA AND NEURODEGENERATIONSingle Cell Gene Expression and cDNA Microarray Analysis to Study Molecular Events in TBI, Neurological Degeneration and RestorationGene Expression Changes Induced by Blocking or Ablation of Nogo A in Spinal Cord Injury and BrainMicroarray Hybridization to Search for Genes Involved in Inhibition and Promotion of Spinal Cord RegenerationProteomics Technology Applied to Traumatic Brain Injury: Implications for the Identification of Diagnostic Predictors and New Therapeutic TargetsMolecular Changes in Neurodegenerative Disorders and Oxidative Stress Responses in Brain InjuryProteomics in Molecular Medicine: Applications to CNS Diseases4. GLYCOMIC TECHNOLOGIES APPLIED TO NERVOUS SYSTEM FUNCTIONGlycomic Approaches to Analyze Neural Functions of Glacosaminoglycans and ProteoglycansGlycoproteomics and Glycan Profiling: Implications for Nervous System Function and Repair
Autoren-Porträt
Hans Werner Müller has been Professor of Molecular Neurobiology at Düsseldorf University since 1993. From 2001 onwards he has acted as the founder of the Neuraxo Biotec GmbH company, where he is also Chairman of the board of directors. He has published more than 150 scientific articles in the field of neurobiology and neuroscience and is an active member of many scientific societies including the American Society for Neurosciences, and the German Society for Neuroscience, where he is chairman of the molecular neurobiology section.
Bibliographische Angaben
- 2008, XV, 234 Seiten, 18 farbige Abbildungen, 18 Schwarz-Weiß-Abbildungen, Maße: 17,8 x 24,5 cm, Gebunden, Englisch
- Herausgegeben: Hans Werner Müller
- Verlag: Wiley-VCH
- ISBN-10: 3527317074
- ISBN-13: 9783527317073
- Erscheinungsdatum: 20.02.2008
Sprache:
Englisch
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