Apoptosis, Senescence and Cancer

Apoptosis, Senescence and Cancer Section I: Apoptosis and Alternative Models of Cell DeathChapter 1. The intrinsic pathway of apoptosis. Scott H. KaufmanChapter 2. The extrinsic pathway of apoptosis. M. Stacey Ricci and Wafik S. El-DeiryChapter 3. Evaluating the importance of apoptosis and other determinants of cell death and survival. Bradley G. Wouters and Roland K. ChiuChapter 4. Mitotic catastrophe. Fiorenza Ianzini and Michael A. MackeyChapter 5. Autophagy and autophagic cell death. Mojgan Djavaheri-Mergny, Joelle Botti and Patrice CodognoChapter 6. Regulation and function of detachment-induced cell death (anoikis) in cancer progression and metastasis. David J. McConkey and Victor Bondar Section II. Telomeres and Telomerase, Senescence, Genomic Instability and TumorigenesisChapter 7. Structure and function of the telomere. Jay E. Johnson and Dominique BroccoliChapter 8. Overview of Senescence. Ruben D. RamirezChapter 9. Contributions of telomerase to tumorigenesis. Richard Possemato and William C. HahnChapter 10. The role of telomeres in genomic instability. John P. Murnane Section III. DNA Damage Response, Signaling Pathways and TumorigenesisChapter 11. Overview of the DNA damage checkpoint -- ATM and ATR. Aude Dupre and Jean GautierChapter 12. Interactions between myc and cyclin dependent kinase inhibitors in cancer. Kirsteen H. Maclean and John L. ClevelandChapter 13. Interplay between H2AX and 53BP1 pathways in DNA double strand break repair response. Fatouros Chronis and Emmy P. RogakouChapter 14. DNA-dependent protein kinase in repair, apoptosis, telomere maintenance and chemotherapy. Lawrence F. Povirk Section IV. Resistance and SensitizationChapter 15. Resistance/signaling pathways. Paul DentChapter 16. Ceramide and multi-drug resistance. Myles C. CabotChapter 17. Chemo and radio-sensitization through inhibition of PI3/Akt signaling. Debra L. Smith, Laura K. Nolden, Gordon B. Mills and Yiling LuChapter 18. The advancement of epidermal growth factor

From the reviews of the second edition:"The book provides a comprehensive view in the field of apoptosis, senescence, and cancer therapies. I recommend this book to PhD students in clinical and experimental oncology, pharmacology as well as to lecturers in biological disciplines." (J. Sedlák, Neoplasma, September, 2008)"This book aims to explain basic biological processes and signalling pathways and to link that knowledge to the anticancer drugs associated with those pathways. ... The book is generally well written and extremely informative. The information within is as up to date ... . I have certainly learnt a lot from reading this book. ... recommending it to a laboratory/clinical group or library for purchase." (A Young, British Journal of Cancer, Vol. 100 (5), 2009)"The purpose of the book is to contribute to an understanding of the growth arrest and cell death pathways mediating the response to chemotherapy in tumour cells. ... provides basic scientists and clinicians with a deeper and more thorough understanding of the cellular responses of malignant cells to common therapeutic modalities, which may determine the effectiveness of the anti-cancer treatment. This work is an interesting overview of the topics described above and it is well written by experts in the field." (Sylvie Rottey, Acta Clinica Belgica, Vol. 65 (2), 2010)