Basic Clinical Radiobiology
(Sprache: Englisch)
This concise but comprehensive textbook sets out the essentials of the science and clinical application of radibiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to...
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Produktinformationen zu „Basic Clinical Radiobiology “
This concise but comprehensive textbook sets out the essentials of the science and clinical application of radibiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer. New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect.
Klappentext zu „Basic Clinical Radiobiology “
This concise but comprehensive textbook sets out the essentials of the science and clinical application of radibiology for those seeking accreditation in radiation oncology, clinical radiation physics and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, the fourth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer. New topics for the fourth edition include chapters on the mechanisms of cell death, biological response modifiers, and biological image guided radiotherapy, with major revisions to sections on the molecular basis of the radiation response, tumour hypoxia and the dose-rate effect.
Inhaltsverzeichnis zu „Basic Clinical Radiobiology “
1.Introduction: the significance of radiobiology and radiotherapy for cancer treatment 2. Irradiation-induced damage and the DNA damage response 3. Cell death after irradiation: how, when and why cells die 4. Quantitating cell kill and cell survival 5. Models of radiation response 5. Dose-response relationships in radiotherapy 6. LET and RBE 7. Tumour growth and response to radiation 8. Fractionation: the L-Q approach 9. The L-Q approach in clinical practice 10. Modified fractionation 11. Time factors in normal-tissue response to radiation 12. The dose-rate effect 13. Pathogenesis of normal-tissue side-effects 14. The volume effect in radiotherapy 15. The oxygen effect and fractionated radiotherapy 16. The tumour microenvironment and cellular hypoxia responses 17. Therapeutic approaches to tumor hypoxia 18. Combined radiotherapy and chemotherapy 19. Retreatment tolerance of normal tissues 20.Molecular image-guided radiotherapy with positron emission tomography 21. Molecular-targeted agents for enhancing tumour response 22. Biological response modifiers in the clinic: tumor 22. Biological response modifiers: normal tissue 23. Molecular targeting and patient individualization 24.Protons and other ions in radiotherapy 25. Second cancers after radiotherapy
Autoren-Porträt
Michael Joiner, Head of the Radiation Biology Program at the Wayne State University, and also Associate Editor of the International Journal of Radiation Biology. Albert van der Kogel, current course director for the Basic Clinical Radiobiology Course at ESTRO, and also Chair of Clinical Radiobiology at the University of Nijmegen, Netherlands.
Bibliographische Angaben
- 2009, 4th ed., 288 Seiten, Maße: 19,9 x 25,4 cm, Gebunden, Englisch
- Ed. by Michael Joiner and Albert van der Kogel
- Herausgegeben: Albert van der Kogel, Michael Joiner
- Verlag: Hodder Education
- ISBN-10: 0340929669
- ISBN-13: 9780340929667
Sprache:
Englisch
Rezension zu „Basic Clinical Radiobiology “
"This is a well written, concise yet comprehensive work covering all important topics in radiobiology." Dooty's
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