Biological Effects of Dietary Restriction

I. Feeding Regimens and Diets.- 1. Terminology and Methods in Dietary Restriction Research.- 2. Nutritional Adequacy in Dietary Restriction.- 3. Significance of Dietary Contaminants in Diet Restriction Studies.- II. Effects of Dietary Restriction on Toxicological Endpoints.- 4. Dietary Restriction and Toxicology Endpoints: An Historical Overview.- 5. Effects of Caloric Restriction on Aflatoxin B1 Metabolism and DNA Modification in Fischer 344 Rats.- 6. Dietary and Caloric Restriction: Its Effect on Cellular Proliferation in Selected Mouse Tissues.- 7. The Impact of Calorie Restriction on Mammary Cancer Development in an Experimental Model.- 8. Pathological Endpoints in Dietary Restricted Rodents - Fischer 344 Rats and B6C3F1 Mice.- 9. Effects of Dietary Restriction on Age-Associated Pathological Changes in Fischer 344 Rats.- 10. Influence of Diet Restriction on Toxicity and Hormonal Status in Chemically Treated Mice.- III. Effects and Mechanisms of Dietary Restriction: Physiological Consequences.- 11. Physiological Consequences of Dietary Restriction: An Overview.- 12. Aging, Dietary Restriction, and Glucocorticoids: A Critical Review of the Glucocorticoid Hypothesis.- 13. The Effect of Dietary Restriction on the Endocrine Control of Reproduction.- 14. Chronic Energy Intake Restriction: Influence on Longevity, Autoimmunity, Immunodeficiency, and Cancer in Autoimmune-Prone Mice.- 15. Behavioral and Neurobiological Effects of Dietary Restriction in Aged Rodents.- 16. Prevention in the Decline of Membrane-Associated Functions in Immune Cells During Aging by Food Restriction.- IV. Effects and Mechanisms of Dietary Restriction: Biochemical Consequences.- 17. Caloric Restriction and Its Effects on Molecular Parameters, Especially DNA Repair.- 18. Prevention of Free RadicalDamage by Food Restriction.- 19. Modifications in Regulation of Intermediary Metabolism by Caloric Restriction in Rodents.- 20. Effects of Long-Term Caloric Restriction on Hepatic Drug-Metabolizing

Leading researchers discuss how a reduced diet may affect the lifespan, susceptibility to tumors and overall physiological and biochemical status of laboratory animals. The implications for future research and human health are included.