Bioorganometallic Chemistry

PrefacePART I: Medicinal ChemistryORGANOMETALLIC COMPLEXES AS ENZYME INHIBITORS: A CONCEPTUAL OVERVIEWIntroductionOrganometallic Compounds as Inert Structural Scaffolds for Enzyme InhibitionOrganometallic Compounds Targeting Specific Protein ResiduesThe Bioisosteric SubstitutionNovel Mechanisms of Enzyme Inhibition with Organometallic CompoundsOrganometallic Compounds as Cargo Delivers of Enzyme InhibitorsOrganometallic Enzyme Inhibitors for Theranostic PurposesConclusionTHE BIOLOGICAL TARGET POTENTIAL OF ORGANOMETALLIC STEROIDSIntroductory Note on Nuclear ReceptorsSteroids and Organometallics: An Overview of the Transitional Period from the Use of Organometallics in Synthesis to the Emergence of BioorganometallicsEpilogCHIRALITY IN ORGANOMETALLIC ANTICANCER COMPLEXESIntroductionChirality in Arene ComplexesCIP System for the Nomenclature of Chiral-at-Metal Arene ComplexesChiral Organometallic Complexes as Anticancer AgentsHalf-Sandwich Complexes with Chiral Metal CentersConclusionsGOLD ORGANOMETALLICS WITH BIOLOGICAL PROPERTIESIntroduction: The Use of Gold in MedicineAnticancer Gold Organmetallics and Proposed Biological TargetsConclusions and PerspectivesON THE MOLECULAR MECHANISMS OF THE ANTIMALARIAL ACTION OF FERROQUINEHistory and DevelopmentMechanism(s) of Action 4-Aminoquinoline AntimalarialsMechanism(s) of Action of Ferroquine as an AntimalarialConclusionMETAL CARBONYL PRODRUGS: CO DELIVERY AND BEYONDIntroducing CO in BiologyTherapeutic Delivery of COBiological and Therapeutic Results Obtained with the Early-Stage CORMsBeyond the Early-Stage CORMs: Strategies for Finding New CandidatesIntracellular Detection of CORMs, Mechanistic Studies, and Other Unanswered QuestionsDesigning Pharmacologically Useful, Drug-like CORMsFinal Remarks and PerspectivesDINITROSYL IRON COMPLEXES WITH NATURAL THIOL-CONTAINING LIGANDS: PHYSICOCHEMISTRY, BIOLOGY, AND MEDICINEIntroductionThe History of Detection and Identification of DNIC with Thiol-Containing Ligands in Microorganisms

Gérard Jaouen obtained his PhD degree in organic chemistry at the University of Rennes, France, in 1969. From 1973 to 1974 he did postdoctoral studies at the University of Cambridge, UK, working with the late Professor (Lord) Jack Lewis. He became a member of the CNRS in 1970, was appointed Directeur de Recherche in 1976 and became Professor at the École Nationale Supérieure de Chimie in Paris in 1982, where in 1984 he set up a CNRS associated research unit. He is now appointed as a "classe exceptionnelle" professor. He is the author of more than 400 papers and holds 14 patents. His achievements in bioorganometallic chemistry have been recognized by several awards. He was awarded "Chevalier dans l'ordre de la Légion d'Honneur" (Knight of the National Order of the Legion of Honour, 2006) and elected as a fellow of the European Academy of Sciences and a member of the Academia Europae in 2012. Michèle Salmain received her PhD degree in organic chemistry from the Université Pierre et Marie Curie, Paris, France in 1990. She has been appointed as a researcher by the Centre National de la Recherche Scientfique (CNRS) since 1992 and currently holds position of Directeur de Recherche. Since the beginning of her academic career, her line of research has lied in the field of bioorganometallic chemistry. Her current interests are focused on the design of immunosensors for analytical applications and artificial metalloenzymes for enantioselective catalysis application