Catalyst Development and Mechanism

PrefaceHIGH-OXIDATION ON STATE MOLYBDENUM AND TUNGSTEN COMPLEXES RELEVANT TO OLEFIN METATHESISIntroductionNew Imido Ligands and Synthetic ApproachesBispyrrolide and Related ComplexesMonoalkoxide Pyrrolide (MAP) ComplexesReactions of Alkylidenes with OlefinsOlefin and Metallacyclopentane ComplexesTungsten Oxo ComplexesBisaryloxidesOther ConstructsConclusionsALKANE METATHESISIntroductionAlkane Metathesis by Single-Catalyst SystemsAlkane Metathesis by Tandem, Dual-Catalytic SystemsConclusionDIASTEREOCONTROL IN OLEFIN METATHESIS: THE DEVELOPMENT OF Z-SELECTIVE RUTHENIUM CATAYLSTSIntroductionThe Challenge of Z-Selective Olefin MetathesisPrevious StrategiesA Serendipitous DiscoveryCatalyst StudiesApplications of Z-Selective Ru Metathesis CatalystsConclusionRUTHENIUM OLEFIN METATHESIS CATALYSTS SUPPORTED BY CYCLIC ALKYL AMINOCARBENES (CAACs)IntroductionProperties and Preparation of CAAC LigandsCAAC-Supported, Ruthenium Olefin Metathesis CatalystsSummarySUPPORTED CATALYSTS AND NONTRADITIONAL REACTION MEDIAIntroductionSupported Catalyst SystemsOlefin Metathesis in Nontraditional MediaConclusionsINSIGHTS FROM COMPUTATIONAL STUDIES ON d0 METAL-CATALYZED ALKENE AND ALKYNE METATHESIS AND RELATED REACTIONSIntroductionAlkene MetathesisAlkyne MetathesisAlkane MetathesisOutlookCOMPUTATIONAL STUDIES OF RUTHENIUM-CATALYZED OLEFIN METATHESISIntroductionComputational Investigations of Non-Chelated Ruthenium CatalystsComputational Investigations of Chelated, Z-Selective Ruthenium CatalystsAccuray of the Computational MethodsINTERMEDIATES IN OLEFIN METATHESISIntroductionMetathesis-Active, Early-Metal MetallacyclesIntermediates in Ruthenium-Catalyzed Olefin MetathesisFuture DirectionsFACTORS AFFECTING INITIATION RATESIntroductionGrubbs Second-Generation CatalystGrubbs-Hoveyda-Type PrecatalystsPyridine SolvatesPiers CatalystsIndenylidene Carbene PrecatalystsZ-Selective CatalystsHerrmann-Type, BisNHCsConclusionsDEGENERATE METATHESISIntroductionDegenerate Metathesis MechanismsDegenerate

Robert H. Grubbs received his Ph.D. from Columbia University for work with Ron Breslow. After a postdoctoral year with Jim Collman at Stanford University, he joined the faculty at Michigan State University. In 1978, he moved to the California Institute of Technology, where he is now the Victor and Elizabeth Atkins Professor of Chemistry. Among many other awards, he received the Nobel Prize in 2005 for his research on the metathesis reaction. His research interests include polymer chemistry, organometallic catalysis, and the development of new synthetic organic methodology.Anna G. Wenzel received her PhD at Harvard University under the guidance of Prof. E. N. Jacobsen. From 2003 to 2006, she joined the group of Prof. R. H. Grubbs as an NIH Postdoctoral Scholar. In 2006, she joined the faculty as an Assistant Professor at the W. M. Keck Science Department in Claremont, California. In 2012, she was promoted to Associate Professor. Her research topics are asymmetric catalysis, organometallic chemistry, and organic synthesis.