Chiral Amine Synthesis

PrefaceSTEREOSELECTIVE SYNTHESIS OF ALPHA-BRANCHED AMINES BY NUCLEOPHILIC ADDITION OF UNSTABILIZED CARBANIONS TO IMINESIntroductionOverview of the Methods for the Preparation of IminesChiral Auxiliary-Based ApproachesCatalytic Asymmetric Nucleophilic Addition to Achiral IminesConclusionASYMMETRIC METHODS FOR RADICAL ADDITION TO IMINO COMPOUNDSBackground and IntroductionIntermolecular Radical Addition Chiral N-AcylhydrazonesAsymmetric Catalysis of Radical AdditionClosing RemarksENANTIOSELECTIVE SYNTHESIS OF AMINES BY CHIRAL BRONSTED ACID CATALYSTSIntroductionCarbon-Carbon Bond Forming ReactionsCarbon-Hydrogen Bond Forming ReactionsCarbon-Heteroatom Bond Forming ReactionsConclusionREDUCTION OF IMINES WITH TRICHLOROSILANE CATALYZED BY CHIRAL LEWIS BASESIntroductionFormamides as Lewis-Basic Organocatalysts in Hydrosilylation of IminesOther Amides as Organocatalysts in Hydrosilylation of IminesSulfinamides as Organocatalysts in Hydrosilylation of IminesSupported Organocatalysts in Hydrosilylation of IminesMechanistic ConsiderationsSynthetic ApplicationsConclusionsTypical Procedures for the Catalytic Hydrosilylation of IminesCATALYTIC, ENANTIOSELECTIVE; VINYLOGOUS MANNICH REACTIONSIntroductionVinylogous Mukaiyama-Mannich Reactions of Silyl DienolatesDirect Vinylogous Mannich Reactions of Unmodified SubstratesMiscellaneousConclusionCHIRAL AMINES FROM TRANSITION-METAL-MEDIATED HYDROGENATION AND TRANSFER HYDROGENATIONScope and Related PublicationsChiral Amines with a Disubstituted Nitrogen Atom, HNR*R1Chiral Amines with Trisubstituted Nitrogen, NR*R1R2ConclusionASYMMETRIC REDUCTIVE AMINATIONIntroductionTransition Metal-Mediated Homogenous Reductive AminationEnantioselective Organocatalytic Reductive AminationDiastereoselective Reductive AminationConclusionsENANTIOSELECTIVE HYDROGENATION OF ENAMINES WITH MONODENTATE PHOSPHORUS LIGANDSIntroductionAsymmetric Hydrogenation of EnamidesAsymmetric Hydrogenation of N,N-Dialkyl EnaminesConclusion and OutlookBIDENTATE LIGANDS FOR

Tom Nugent gained his Ph.D. in Organic Chemistry in 1995 from Virginia Tech working with Professor Tomas Hudlicky. From 1996-1997, he completed his postdoctoral studies at the University of Liverpool (Great Britain) with Professor Stanley Roberts. Over the next six years he worked as a process research chemist, first with Catalytica Fine Chemicals / DSM (Mountain View, California, 1998-2000) and then with Pharmacia/Pfizer Corporation (South San Francisco, California, 2001-2003). In 2004 he began his academic career at Jacobs University as Assistant Professor of Organic Chemistry.Tom Nugent gained his Ph.D. in Organic Chemistry in 1995 from Virginia Tech working with Professor Tomas Hudlicky. From 1996-1997, he completed his postdoctoral studies at the University of Liverpool (Great Britain) with Professor Stanley Roberts.Over the next six years he worked as a process research chemist, first with Catalytica Fine Chemicals / DSM (Mountain View, California, 1998-2000) and then with Pharmacia/Pfizer Corporation (South San Francisco, California, 2001-2003). In 2004 he began his academic career at Jacobs University as Assistant Professor of Organic Chemistry.