Click Chemistry and DNA Binders
Synthesis and interaction studies of pi- conjugated DNA binders through click chemistry
(Sprache: Englisch)
This book provides an overview in recent progress in the field of synthesis and interactions of pi-conjugated DNA binders through Click chemistry. The synbook of alkyne- and azide substituted oligoheteroaromatic compounds, were designed to be used as...
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This book provides an overview in recent progress in the field of synthesis and interactions of pi-conjugated DNA binders through Click chemistry. The synbook of alkyne- and azide substituted oligoheteroaromatic compounds, were designed to be used as building blocks for Click reactions. The Pd-catalysed cross-coupling of azide-substituted building blocks to form oligoheteroaromatics is also described. The characterisation of the new pi-conjugated molecules utilising Click chemistry between alkyne- and azide-substituted compounds leading to a series of structurally-varied di- and tricationic oligoheteroaromatic putative DNA binders. The DNA-binding studies for the di- and tricationic oligoheteroaromatic compounds using a variety of biophysical techniques to quantify DNA binding and elucidate binding modes. Finally, the overall conclusions of the study, including future studies and applications are presented.
Bibliographische Angaben
- Autor: Ismail Althagafi
- 2014, 364 Seiten, Maße: 22 cm, Kartoniert (TB), Englisch
- Verlag: LAP Lambert Academic Publishing
- ISBN-10: 3848411423
- ISBN-13: 9783848411429
Sprache:
Englisch
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