Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy
(Sprache: Englisch)
This book explores a large population-based data set evaluating congenital anomalies as a consequence of maternal diseases. The authors review 50 years' experience in human teratology, expose weaknesses of earlier studies and offer tips for design of new ones.
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This book explores a large population-based data set evaluating congenital anomalies as a consequence of maternal diseases. The authors review 50 years' experience in human teratology, expose weaknesses of earlier studies and offer tips for design of new ones.
Klappentext zu „Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy “
The major objective of our studies in the last decade was a systematic analysis of maternal diseases during pregnancy to reveal their possible adverse effects on birth outcomes. The two most important factors of infant mortality were parti- larly analyzed: structural birth defects, known as congenital abnormalities (CAs) and preterm birth (PB). In general the objectives of scienti c studies might be either to test a new hypothesis or to con rm or confront previously published results. However, less frequently the authors/scientists have personal motivations determined by their professional activities. The authors of this book are practicing physicians and genetic epidemiologist who are mainly interested in the following three practical questions: 1. The possible adverse effects of pharmaceutical products. The possible t- atogenic potential of about 170 drugs has been evaluated very thoroughly using the data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) in the last 50 years. These drugs were used to treat maternal diseases and the ndings of our population-based case-control studies will be cited in this book and are shown in the Appendix at the end of the book. However, our long experiences showed two problems in the drug teratology. In general the evaluation of clinical doses of these drugs is a particularly dif- cult challenge due to the modi cation effects of confounders. This problem motivated one of the authors to establish a new model of disaster epidemiology.
Inhaltsverzeichnis zu „Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy “
INTRODUCTIONPART A. THE STUDY POPULATION AND METHODS (Andrew E. Czeizel)I. The Hungarian Congenital Abnormality Registry (HCAR)II. The Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA)III. Preterm birth and low birth weight newbornsIV. The Budapest Monitoring System of Self-poisoning Pregnant WomenPART B. RESULTS OF STUDIES AND THEIR INTERPRETATION (Nándor Ács and Ferenc Bánhidy)I. Certain infectious and parasitic diseasesII. NeoplasmsIII. Diseases of blood and blood-forming organsIV. Endocrine, nutritional and metabolic diseasesV. Mental and behavioural disordersVI. Diseases of the nervous systemVII. Diseases of eye and adnexaVIII. Diseases of ear and mastoid processIX. Diseases of the circulatory systemX. Diseases of the respiratory systemXI. Diseases of the digestive systemXII. Diseases of skin and subcutaneous tissueXIII. Diseases of the musculoskeletal system and connective tissueXIV/A. Diseases of urinary tractXIV/B. Diseases of genital organsXV. Pregnancy, childbirth and puerperiumXVI. Congenital malformations, deformities and chromosomal abnormalitiesPART C: SUMMARY OF RESULTS AND RECOMMENDATIONS (Nándor Ács, Ferenc Bánhidy and Andrew E. Czeizel)A/ Association of maternal diseases during pregnancy with higher risk of congenital abnormalities (CAs) in their childrenI. High fever related maternal diseases during pregnancy and CAs in their offspringII. Confirmed associations of maternal diseases with CAIII. Unexpected associations of maternal diseases during pregnancy with a higher risk of CA in their childrenIV. Teratogenic potential of related drugs treatmentV. Maternal diseases with preventive effect of CAsVI. Primary prevention of CAsB/ Association of maternal diseases withthe higher risk of preterm birth (PB) and low birth weight (LBW) newbornsI. Local causesII. Microbial causesIII. Chronic maternal diseases during the study pregnancyIV. Pregnancy complications during the study pregnancyV. Prevention of PB and LBW newborns
Bibliographische Angaben
- 2014, 2010., 532 Seiten, Maße: 23,5 cm, Kartoniert (TB), Englisch
- Herausgegeben:Ács, Nándor; Bánhidy, Ferenc G.; Czeizel, Andrew E.
- Verlag: Springer Netherlands
- ISBN-10: 9401784329
- ISBN-13: 9789401784320
Sprache:
Englisch
Rezension zu „Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy “
From the reviews:"In this presentation of the Hungarian Congenital Abnormality Registry, the authors use a large case-control analysis to determine the risk of pregnancy malformations in a variety of maternal conditions. ... The audience includes obstetricians or practitioners involved in high-risk obstetrics. ... This is an ambitious presentation of one country's risk of congenital abnormalities and preterm birth." (Anthony Shanks, Doody's Review Service, October, 2010)
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