Dynamic Combinatorial Chemistry

HISTORY AND PRINCIPLES OF DYNAMIC COMBINATORIAL CHEMISTRY Introduction History Exercising Control over a DCL to Influence Species Distribution Designing a Dynamic Combinatorial System Conclusions THE PRACTICE OF DYNAMIC COMBINATORIAL LIBRARIES: ANALYTICAL CHEMISTRY, EXPERIMENTAL DESIGN, AND DATA ANALYSIS Introduction Analytical Methods Experimental Design Data Analysis Conclusions DEVELOPMENT OF SYNTHETIC RECEPTORS USING DYNAMIC COMBINATORIAL CHEMISTRY Introduction Experimental Considerations Selected Examples Conclusion DYNAMIC COMBINATORIAL CHEMISTRY FOR CATALYTIC APPLICATIONS Introduction Dynamic Combinatorial Approaches to Cage Catalysts Dynamic Combinatorial Approaches to Transition Metal Catalysts Conclusions DYNAMIC COMBINATORIAL CHEMISTRY: LIGANDS FOR BIOMOLECULES Ligand Discovery DCC Strategies in Targeting Biological Systems Dynamic Diversity Generation for Biological Systems Applications of DCC in Biological Systems Conclusions and Future Prospects POLYMERS FORMED BY DYNAMIC COMBINATORIAL CHEMISTRY Introduction Dynamics in Polymers Biasing Composition by Molecular Recognition Conclusions and Outlook ANALYTICAL APPLICATIONS OF DYNAMIC COMBINATORIAL CHEMISTRY Introduction Fluorescent Sensors Colorimetric Sensors Molecular Timers Conclusions TRENDS AND PERSPECTIVES Introduction Dynamic Combinatorial Libraries as Molecular Networks Perspectives

Joost Reek received his PhD in 1996 under Prof. R.J.M. Nolte in the field of supramolecular chemistry. Following this, he joined Prof. M.J. Crossley?s group in Sydney as a postdoctoral fellow, where he gained experience in porphyrin chemistry and Dendrimers. In 1998 he became a lecturer in the group headed by Prof. P.W.N.M. Van Leeuwen with research activities focusing on transition metal catalysis, and during this period began his own line of research into Supramolecular transition metal chemistry. He has received numerous grants, including the prestigious VICI grant, and in 2005 became a member of the young Royal Netherlands Academy of Arts and Sciences (KNAW). One year later he was appointed full professor at the University of Amsterdam. Dr. Reek currently heads a research group of about 30 people, comprising 18 PhD students and 8 postdocs, working on various topics related to supramolecular chemistry and transition metal catalysis.Sijbren Otto received his Ph.D. degree in physical organic chemistry from the University of Groningen in the Netherlands in the group of Prof. Jan B.F.N. Engberts. After one year in the United States as a postdoctoral researcher with Prof. Steven L. Regen (Lehigh University, Bethlehem, Pennsylvania) he received a Marie Curie Fellowship and moved to the University of Cambridge, where he worked for two years with Prof. Jeremy K.M. Sanders on dynamic combinatorial libraries. He started his independent research career in 2001 as a Royal Society University Research Fellow in Cambridge. In 2009 he moved to the University of Groningen in the Netherlands where he is associated with the newly created Centre for Systems Chemistry.