Efflux-Mediated Antimicrobial Resistance in Bacteria

I-Bacterial drug efflux pumps: structures and transport mechanisms.- 1.Structures and transport mechanisms of RND efflux pumps.- 2.Structural and molecular landscape of MFS and MATE efflux pumps.- 3.Small multidrug resistance efflux pumps.- 4.Structures and transport mechanisms of the ABC efflux pumps.- 5.Multidrug efflux in the context of two-membrane cell envelopes.- II-Bacterial drug efflux pumps in antimicrobial resistance: substrates, regulation and clinical significance.- 6.Antimicrobial resistance in bacteria: an overview of mechanisms and role of drug efflux pumps.- 7.Antimicrobial drug efflux pumps in Staphylococcus aureus.- 8.Antimicrobial drug efflux pumps in other Gram-positive bacteria.- 9.Antimicrobial drug efflux pumps in Escherichia coli.- 10.Antimicrobial drug efflux pumps in Salmonella.- 11.Antimicrobial drug efflux pumps in Enterobacter and Klebsiella.- 12.Antimicrobial resistance and drug efflux pumps in Vibrio and Legionella.- 13.Antimicrobial resistance and drug efflux pumps in Acinetobacter.- 14.Antimicrobial drug efflux pumps in Pseudomonas aeruginosa.- 15.Antimicrobial drug efflux pumps in Stenotrophomona maltophilia.- 16.Antimicrobial drug efflux pumps in Burkholderia.- 17.Efflux pumps in Neisseria gonorrhoeae: contributions to antimicrobial resistance and virulence.- 18.Efflux pumps in Campylobacter: key players for antimicrobial resistance and environmental adaption.- 19.Antimicrobial resistance and drug efflux pumps in Helicobacter.- 20.Antimicrobial resistance and drug efflux pumps in Bacteroides.- 21.Efflux pumps in mycobacteria: antimicrobial resistance, physiological functions, and role in pathogenicity.- 22.Antimicrobial drug efflux genes and pumps in bacteria of animal and environmental origin.- 23.Role of plasmid-encoded drug efflux pumps in antimicrobial resistance.- 24.Influence of regulatory RNAs on antimicrobial resistance and efflux mechanisms.- III.Role of drug efflux pumps beyond antimicrobial resistance: natural

XIAN-ZHI LI, M.D., Ph.D., is a Team Leader at the Veterinary Drugs Directorate of Health Canada for regulation of drug products, dealing with microbiological and toxicological safety assessments of drugs as well as antimicrobial drug policy. Dr. Li received his medical degree and a M.Sc. in Pharmacology, respectively, from Luzhou Medical College and West China University of Medical Sciences (WCUMS [now Sichuan University]; with Dr. Yu-Sheng Wang) in China in the 1980s, followed by a faculty appointment in Pharmacology at WCUMS. He later obtained another M.Sc. and Ph.D. in Microbiology from the University of Saskatchewan (with Dr. Kurt E. Williams) and Queen's University, Kingston (with Dr. Keith Poole) in Canada, respectively. He has been actively involved for over a decade in the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) under the Public Health Agency of Canada. He is also an advisor to the Veterinary Antimicrobial Susceptibility Testing Subcommittee of the Clinical and Laboratory Standards Institute (CLSI). He has published over 80 peer-reviewed articles on antimicrobial resistance with notable contributions to the seminal discovery and characterization of RND drug efflux pumps of Pseudomonas and Stenotrophomonas at the University of California, Berkeley (with Dr. Hiroshi Nikaido) and Queen's University. His interests include antimicrobial resistance evolution, mechanisms and risk assessment.



CHRISTOPHER A. ELKINS, Ph.D., is Director of the Division of Molecular Biology at the Center for Food Safety and Applied Nutrition (CFSAN), US Food and Drug Administration (FDA). Dr. Elkins received a Bachelor of Arts degree in Biology and History from Case Western Reserve University in 1994 and a Ph.D. degree in Microbiology from the University of Tennessee, Knoxville in 2001 under the mentorship of Dr. Dwayne C. Savage. He subsequently was appointed as postdoctoral fellow in the

"This extraordinarily comprehensive book covers the efflux pumps of several important bacterial genera regarding types of pumps, regulation of the pumps, and contribution of the pumps to antibiotic resistance. ... audience includes anyone in the scientific field of antibiotic resistance. ... appropriate for students and seasoned researchers. Infectious disease physicians also may find it helpful with respect to mechanisms of resistance and antibiotic stewardship. ... I am not aware of a more comprehensive book on efflux-mediated resistance than this one." (Nancy D. Hanson, Doody's Book Reviews, February, 2017)