Evolution, Modularity, and Dynamics of Gene Regulatory Networks
(Sprache: Englisch)
This book studies the interplay between gene regulatory networks, phenotype and evolution via a combination of concept, theory and experiment. At the conceptual level, the author demonstrates thatgenes in regulatory networks group into surprisingly...
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This book studies the interplay between gene regulatory networks, phenotype and evolution via a combination of concept, theory and experiment. At the conceptual level, the author demonstrates thatgenes in regulatory networks group into surprisingly well-defined evolutionary modules with distinctive rates of evolution and conserved patterns of gene expression. At the theoretical level, the authordevelops a a novel probabilistic model for estimating the phylogeny of a pathway. Finally, the author analyses experimental data to reveal that genes sharing expression patterns (transcriptional modules) are not always evolutionarily conserved, but that genes sharing phylogenetic patterns (evolutionary modules) are typically co-expressed. These comparative approaches begin the attempt towardsa system-level understanding of how evolution is linked to the design and dynamics of regulatory networks, and how these networks functionacross timescales from microseconds to eons.
Autoren-Porträt von Amoolya Singh
Singh, AmoolyaBorn and raised in India, Dr. Amoolya Hardev Singh graduated with honors in Biology & Computer Science from Carnegie Mellon University, and earned a Ph.D. from U.C. Berkeley in computational biology. She is currently a postdoctoral researcher at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany.
Bibliographische Angaben
- Autor: Amoolya Singh
- 2008, 140 Seiten, Maße: 15 x 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller e.K.
- ISBN-10: 3836494469
- ISBN-13: 9783836494465
- Erscheinungsdatum: 04.12.2013
Sprache:
Englisch
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