Genome Editing
The Next Step in Gene Therapy
(Sprache: Englisch)
This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian...
Jetzt vorbestellen
versandkostenfrei
Buch (Gebunden)
149.79 €
74 DeutschlandCard Punkte
sammeln
- Lastschrift, Kreditkarte, Paypal, Rechnung
- Kostenlose Rücksendung
- Ratenzahlung möglich
Produktdetails
Produktinformationen zu „Genome Editing “
Klappentext zu „Genome Editing “
This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and peptide nucleic acids, aptamer-guided gene targeting, AAV gene editing via DSB repair, engineered nucleases and trinucleotide repeat diseases, and creation of HIV-resistant cells. The expertly authored chapters contextualize current developments within the history of genome editing while also discussing the current and potential safety concerns of this rapidly growing field.Genome Editing: The Next Step in Gene Therapy, the latest volume in the American Society of Gene and Cell Therapy series, deftly illuminates the potential of genetic engineering technology to eradicate today's deadliest and most prolific diseases. It is ideal reading for clinicians and researchers in genetics and immunology.
Inhaltsverzeichnis zu „Genome Editing “
1. Gene Editing: Double-Strand Break Induced Gene Targeting and Mutagenesis 20 Years Later.- 2. The Development and Use of Zinc-Finger Nucleases.- 3.The Use and Development of TAL Effector Nucleases.- 4. Genome Editing for Neuromuscular Diseases.- 5. Phage Integrases for Genome Editing.- 6. Precise Genome Modification Using Triplex Forming Oligonucleotides and Peptide Nucleic Acids.- 7. Genome Editing by Aptamer-Guided Gene Targeting.- 8. Stimulation of AAV Gene Editing via DSB Repair.- 9. Engineered Nucleases and Trinucleotide Repeat Diseases.- 10. Using Engineered Nucleases to Create HIV-Resistant Cells.- 11. Strategies to Determine Off-Target Effects of Engineered Nucleases.
Autoren-Porträt
Matthew Hirsch, PhD is an Assistant Professor of Ophthalmology at the University of North Carolina (UNC) at Chapel Hill in Chapel Hill, North Carolina. He also holds appointments in Microbiology and Immunology and in Genetics and MolecularBiology, as well as in the Gene Therapy Center at UNC. Dr. Hirsch received his PhD from West Virginia University in Morgantown, WV; his studies focused on E.coli and Salmonella genetics. He completed his post-doctoral research at UNC studying both episomal and chromosomal genetic engineering using adeno-associated virus (AAV). Dr. Hirsch continues these basic AAV studies and has several reagents under preclinical evaluation for the treatment of blindness and muscular dystrophies. Toni Cathomen, PhD is Professor and Director of the Institute for Cell and Gene Therapy at the University Medical Center Freiburg, in Freiburg, Germany. The Institute provides the Medical Center with blood and cell products as well as all transfusion and transplantation related diagnostic services. Dr. Cathomen received his PhD from the University of Zurich, in Zurich, Switzerland. Before his appointment in Freiburg, he was a postdoctoral fellow at the Salk Institute in San Diego, California, USA; Assistant Professor of Molecular Virology at Charité Medical School in Berlin, Germany; and Associate Professor of Experimental Hematology at Hannover Medical School in Hannover, Germany. Dr. Cathomen's main research goals are to further improve safe genome editing tools (including TALENs, CRISPR/Cas9) for therapeutic applications in human stem cells, to develop disease models and cell therapies based on induced pluripotent stem cells (iPSCs), and to translate cell and gene therapy efforts into the clinic.
... mehr
Dr. Matthew Porteus is an Associate Professor at Stanford Medical School in Stanford, California, and attends clinically at the Lucille Packard Children's Hospital in Palo Alto, California. Dr. Porteus received a combined MD, PhD from Stanford Medical School. After completing a fellowship with the Boston Children's Hospital in conjunction with the Dana Farber Cancer Institute, both in Boston, Massachusetts, he did post-doctoral research at both the Massachusetts Institute of Technology in Cambridge, Massachusetts and the California Institute of Technology in Pasadena, California. Following these, he held an independent faculty position at University of Texas- Southwestern in Dallas, Texas in the Departments of Pediatrics and Biochemistry before assuming his current position. In his research, Dr. Porteus focuses on the development of genome editing by homologous recombination as curative therapy for children with genetic diseases. He is also interested in the clonal dynamics of heterogeneous populations and the use of genome editing to better understand pediatric disease, including infant leukemias and muscular genetic disorders.
... weniger
Bibliographische Angaben
- 2016, 1st ed. 2016, XVI, 263 Seiten, 43 farbige Abbildungen, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Toni Cathomen, Matthew Hirsch, Matthew Porteus
- Verlag: Springer, Berlin
- ISBN-10: 1493935070
- ISBN-13: 9781493935079
- Erscheinungsdatum: 05.03.2016
Sprache:
Englisch
Kommentar zu "Genome Editing"
0 Gebrauchte Artikel zu „Genome Editing“
| Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
|---|
Schreiben Sie einen Kommentar zu "Genome Editing".
Kommentar verfassen