Genomic Clinical Trials and Predictive Medicine
(Sprache: Englisch)
This book focuses on novel approaches that provide a reliable basis for identifying what kinds of patients are likely to benefit from the each new treatment.
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This book focuses on novel approaches that provide a reliable basis for identifying what kinds of patients are likely to benefit from the each new treatment.
Klappentext zu „Genomic Clinical Trials and Predictive Medicine “
Genomics is majorly impacting therapeutics development in medicine. This book contains up-to-date information on the use of genomics in the design and analysis of therapeutic clinical trials with a focus on novel approaches that provide a reliable basis for identifying which patients are most likely to benefit from each treatment. It is oriented to both clinical investigators and statisticians. For clinical investigators, it includes background information on clinical trial design and statistical analysis. For statisticians and others who want to go deeper, it covers state-of-the-art adaptive designs and the development and validation of probabilistic classifiers. The author describes the development and validation of prognostic and predictive biomarkers and their integration into clinical trials that establish their clinical utility for informing treatment decisions for future patients.
Inhaltsverzeichnis zu „Genomic Clinical Trials and Predictive Medicine “
1. Clinical trial basics; 2. Actionable prognostic biomarkers; 3. Phase II designs; 4. Enrichment designs; 5. Including both test positive and test negative patients; 6. Adaptive threshold design; 7. Multiple predictive biomarkers predictive analysis of clinical trials; 8. Prospective - retrospective design; Appendix A. Statistics background; Appendix B. Prognostic classifiers based on high dimensional data.
Bibliographische Angaben
- Autor: Richard M. Simon
- 150 Seiten, Maße: 24,6 x 0,3 cm, Kartoniert (TB), Englisch
- Verlag: Cambridge University Press
- ISBN-10: 1107401356
- ISBN-13: 9781107401358
Sprache:
Englisch
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