High Pressure Bioscience

Part I Why and How Proteins Denature under Pressure?.- 1 Early Days of Pressure Denaturation Studies of Proteins.- 2 Protein Denaturation on p-T Axes - Thermodynamics and Analysis.- 3 Driving Forces in Pressure-induced Protein Transitions.- 4 Why and How Does Pressure Unfold Proteins?.- Part II Volume, Compressibility, Fluctuation and Interaction in Proteins.- 5 Volume and Compressibility of Proteins.- 6 Pressure-Dependent Conformation and Fluctuation in Folded Protein Molecules.- 7 Water Turns the "Non-Biological" Fluctuation of Protein into "Biological" One.- 8 Pressure Effects on the Intermolecular Interaction Potential of Condensed Protein Solutions.- Part III  Pressure and Functional Sub-States in Proteins.- 9 High Pressure NMR Methods for Characterizing Functional Sub-States of Proteins.- 10 High-Pressure NMR Spectroscopy Reveals Functional Sub-States of Ubiquitin and Ubiquitin-Like Proteins.- 11 Functional Sub-States of Proteins by Macromolecular Crystallography.- 12 Cavities and Excited States in Proteins.- Part IV  Pressure and Protein Folding and Assembly.- 13 Exploring the Protein Folding Pathway with High-Pressure NMR: Steady-State and Kinetic Studies.- 14 Basic Equations in Statics and Kinetics of Protein Polymerization and the Mechanism of the Formation and Dissociation of Amyloid Fibrils Revealed by Pressure Perturbation.- 15 Pressure-Inactivated Virus: a Promising Alternative for Vaccine Production.- Part V  Pressure Effects on Biological Membranes.- 16 How Do Membranes Respond to Pressure?.- 17 Pressure Effects on Artificial and Cellular Membranes.- 18 Effects of High Hydrostatic Pressure on Microbial Cell Membranes: Structural and Functional Perspectives.- 19 Homeoviscous Adaptation of Membranes in Archaea.- Part VI  Pressure adaptation and tolerance of proteins and living organisms.- 20 Pressure-Dependent Gene Activation in Yeast Cells.- 21 Environmental Adaptation of Dihydrofolate Reductase from Deep-Sea Bacteria.- 22 Moss