Introduction to Translational Cardiovascular Research

Introduction - What Is Translational Research.- Insights into heart development and regeneration.- Basis Of Cell Excitability And Cardiac Conduction System.- The Renin-Angiotensin-Aldosterone System In Cardiovascular Diseases.- Beta adrenergic receptors.- The hypothalamic-pituitary-adrenal axis in human health and disease.- Genetic Polymorphisms.- Genetic Polymorphisms and the Vascular Endothelium.- The role of microRNAs in Cardiovascular Disease.- Pathways To Myocardial Hypertrophy.- The multiple actions of the insulin-like growth factor-I signaling in the myocardium.- Calcium Cycling Circuits in Cardiac Physiology and Pathophysiology.- Inflammation and atherosclerosis.- Stress proteins and the Adaptive Response of the Heart.- The Mechanisms And Modalities Of Cell Death.- Repair of the infarcted myocardium.- Pathways to cardiac remodeling.- A Translational Approach to Probe the Arrhythmic Potential of the Heart: Therapeutic Considerations.- Animal Models Of Cardiovascular Disease.- Experimental in vitro assessment of cardiac function.- In vivo experimental assessment of cardiac function.- Non invasive imaging modalities for Cardiovascular Translational Research- Technical Considerations.- Cardiovascular Applications of Non-Invasive Imaging in Cardiovascular Diseases: from Bench to Bedside.- Molecular Imaging of Inflammation Using Echoardiography: Advances With the Use of Microbubbles.- Clinical Aspects And Genetics Of Cardiomyopathies.- Cardiorenal Syndrome: What Basic Research Can Contribute.- Clinical aspects of Cardiorenal Syndrome: consequences of therapy with the Renin-Angiotensin System Inhibitors.- Pre-, Peri-, and Post-Conditioning the ischemic myocardium: Challenges, Confounders and Expectations.- Gene Therapy for the Heart.- Cell therapy in cardiac diseases.- Moving Towards a Novel Paradigm in Drug Development for Worsening Heart Failure: The T1 Model (Mechanistic Translational Phase).

"The book fulfills its purpose of providing a deeper understanding of translational research in cardiovascular diseases. ... This will be useful to all in the cardiovascular field, including practicing cardiologists, trainees, researchers, statisticians, internists, nurse practitioners, house staff and the general population. ... This is a most comprehensive collection of measures and assessment tools related to translational cardiovascular research. It demonstrates the importance of the application of knowledge acquired from basic research to the practical ends in this area." (Fahad Javed, Doody's Book Reviews, April, 2015)