Lyophilization of Biopharmaceuticals
(Sprache: Englisch)
Humans have been experimenting with lyophilization, or freeze-drying, as a method to preserve biological structures for over a thousand years.
This comprehensive volume, intended for scientists in both academia and industry, covers a wide range of topics...
This comprehensive volume, intended for scientists in both academia and industry, covers a wide range of topics...
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Klappentext zu „Lyophilization of Biopharmaceuticals “
Humans have been experimenting with lyophilization, or freeze-drying, as a method to preserve biological structures for over a thousand years.This comprehensive volume, intended for scientists in both academia and industry, covers a wide range of topics relevant to the formulation of peptide and protein drugs in the freeze-dried state.
Inhaltsverzeichnis zu „Lyophilization of Biopharmaceuticals “
Lyophilization Equipment.- Validation of Lyophilization.- Heat and Mass Transfer in Freeze-drying Process Development.- Freeze-drying Process Development for Protein Pharmaceuticals.- Excipients for Use in Lyophilized Pharmaceutical Peptide, Protein, and other Bioproducts.- The Role of Water in Physical Transformations in Freeze-dried Products.- Thermal Analysis of Lyophilized Pharmaceutical Peptide and Protein Formulations.- Microscopy of Lyophilized Proteins.- Thermodynamics and Dynamics of Glassforming Systems.- Physical Damage to Proteins During Freezing, Drying and Rehydration.- Degradation Pathways for Lyophilized Peptides and Proteins.- Stabilization of Lyophilized Proteins Encapsulated in Controlled-release Polymers.- Spray Freeze-drying of Biopharmaceuticals.- Freeze-drying of Liposomes.- Physical Stabilization of Plasmid DNA-based Therapeutics During Freezing and Drying.- Dehydrated Protein Powders as Biocatalysts in Nonaqueous Solvents.
Bibliographische Angaben
- 2006, 686 Seiten, Maße: 25,4 cm, Gebunden, Englisch
- Ed. by H. Costantino and M. Pikal
- Verlag: Springer
- ISBN-10: 0971176760
- ISBN-13: 9780971176768
Sprache:
Englisch
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