Modulation of Protein Stability in Cancer Therapy
(Sprache: Englisch)
This comprehensive monograph on the role of protein modulation in cancer therapeutics focuses on targeting molecules that regulate protein stability in a variety of tumors. Topics covered include ubiquitin ligases, deubiquitinating enzymes, and the proteasome.
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This comprehensive monograph on the role of protein modulation in cancer therapeutics focuses on targeting molecules that regulate protein stability in a variety of tumors. Topics covered include ubiquitin ligases, deubiquitinating enzymes, and the proteasome.
Klappentext zu „Modulation of Protein Stability in Cancer Therapy “
This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome. Specific diseases resulting from deregulated ubiquitin ligases, such as Von-Hippel-Lindau disease and Fanconi anemia are also discussed. Finally, novel approaches and drugs to target proteins involved in sumoylation, ubiquitination, and degradation are described.
Inhaltsverzeichnis zu „Modulation of Protein Stability in Cancer Therapy “
protacs chimeric molecules to target cancer causing proteins for ubiquitination and degradation.- topors and sumoylation in cancer therapy.- ubistatins.- novel proteasome inhibitors.- MDM2 inhibitors.- HSP90 inhibitors in cancer therapy.- novel proteasome inhibitors in multiple myeloma.- novel HDAC6 inhibitor.- histone deacetylase inhibitors in prostate cancer.- the role of ISG15 in carcinogenesis
Bibliographische Angaben
- 2009, 2009 edition, 165 Seiten, Maße: 16,6 x 24,4 cm, Gebunden, Englisch
- Herausgegeben:Sakamoto, Kathleen; Rubin, Eric
- Herausgegeben: Kathleen Sakamoto, Eric Rubin
- Verlag: Springer, New York
- ISBN-10: 038769143X
- ISBN-13: 9780387691435
- Erscheinungsdatum: 01.05.2009
Sprache:
Englisch
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