Molecular Genetics of Liver Neoplasia
(Sprache: Englisch)
Primary liver cancer is the third most deadly and fifth most common cancer worldwide. This book offers an exciting overview of the advances in the genetics and biology of liver cancer, diagnosis, treatment and prevention.
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Primary liver cancer is the third most deadly and fifth most common cancer worldwide. This book offers an exciting overview of the advances in the genetics and biology of liver cancer, diagnosis, treatment and prevention.
Klappentext zu „Molecular Genetics of Liver Neoplasia “
Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor's aggressiveness at the time of diagnosis and the lack of effective therapy.
Inhaltsverzeichnis zu „Molecular Genetics of Liver Neoplasia “
Part I: Introduction
1. Overview of HCC: biology and pathology
Xin Wei Wang, Joe Grisham and Snorri Thorgeirsson
2. Overview of CC:
Part II: Liver development and pathogenesis
3. Embryonic development of the liver
Kenneth S. Zaret
4. Human hepatic cell lineages
Nelson Fausto
5. Pathology of Human Liver Cancer
Masamichi Kojiro
Part III: Genetics and epidemiology of liver cancer
6. HCC
Hashem El.Serag
7. CC
Greg Gores
Part IV: Molecular Basis of Cancer Susceptibility
8. Yusuke Nakamura (NCC)
9. Hereditary liver diseases with a high risk to develop HCC
Markus Grompe, [ALSO Marie-Annick Buendia]
10. Genetics and epigenetics of preneoplastic liver diaseses and human HCC
11. HBV: Jack Wands
12. HCV: Stanly Lemon
13. Fibrosis and cirrhosis studies
David Brenner
14. Methylation status in chronic liver disease and HCC
Yae Kanai (Japan)
Part V. Animal models
15. Transgenic mouse models
Snorri Thorgeirsson & Joe Grisham
16. Mosaic mouse model
Scott Lowe
17. Zebrafish model
Zhiyuan Gong (NUS):
Part VI: Global gene expression profiling of human liver cancer
18. Integrative and functional genomics of HCC
Snorri Thorgeirsson:
19. Molecular signatures of metastatic HCC
Xin Wei Wang
20. Liver cancer heterogeneity and tumor subtypes
Jessica Rossi
21. Gene expression studies in cholangiocarcinoma
Yoichi Furokawa
Part VII: Cancer stem cells
22. Snorri Thorgeirsson
23. Tania Roskams
Part VIII: Liver cancer genetics in the clinic
24. Biomarkers and clinical staging of liver cancer
Josep Llovet
25. Molecular signaling in HCC
Hong Yang Wang (Shanghai)
26. Molecular oncology and HCC
Zhao-You Tang (Shanghai)
27. Molecular pathogenesis of HCC
Irene Ig (Hong Kong)
Bibliographische Angaben
- 2010, 2011., 399 Seiten, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben:Wang, Xin Wei; Grisham, Joe W.; Thorgeirsson, Snorri S.
- Herausgegeben: Xin Wei Wang, Snorri S. Thorgeirsson, Joe W. Grisham
- Verlag: Springer, New York
- ISBN-10: 1441960813
- ISBN-13: 9781441960818
- Erscheinungsdatum: 08.11.2010
Sprache:
Englisch
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