Molecular Motors

BASIC PRINCIPLES OF MOTOR DESIGN Myosin Superfamily: An Overview (Kieke, Titus)Dynein Motors: Structure, Mechanochemistry and Regulation (King)Kinesin Superfamily Proteins (Hirokawa, Takemura)The Bacterial Flagellar Motor (Berry)F1-Motor of ATP Synthase (Noji)RNA and DNA Polymerases (Korzheva, Mustaev)Helicases as Molecular Motors (Levin, Patel)MECHANOCHEMISTRYHow Protein Motors Convert Chemical Energy into Mechanical Work (Oster, Wang)Example Models to Illustrate the Difference between Ratchets and Power StrokesA Closer Look at Binding Free EnergyMolecular Motor Directionality (Endow)Kinesins: Processivity and Chemomechanical Coupling (Hancock, Howard)Qantitative Measurements of Myosin Movement In Vitro: The Reductionist Approach Carried to Single Molecules (Spudich)Structure of Kinesin Motor Domains: Implications for Conformational Switching Involved in Mechanochemical Coupling (Song, Marx, Mandelkow)Single Molecule Measurements and Molecular Motors (Ishii, Yanagida)FUNCTIONAL IMPLICATIONSMitotic Spindle Motors (Scholey, Mogilner)The Roles of Molecular Motors in Generating Developmental Asymmetry (Fischer)Motors and Membrane Trafficking (Verhey)Regulation of Molecular Motors (Haimo)Molecular Motors in Plant Cells (Reddy)MOTORS IN DISEASEMyosin Myopathies (Konhilas, Leinwand)The Role of Dynein in Disease (Vallee, Tai)Molecular Motors in Sensory Defects (Avraham)BEYOND BIOLOGICAL APPLICATIONSSystematized Engineering of Biomotor-powered Hybrid Devices (Schmidt, Montemagno)Synthetic Molecular Motors (Delden, Wiel, Koumura, Feringa)

"...essential reading for graduate students in the field of cell motility and molecular motors...recommend it enthusiastically..."Nature Cell Biology, Vol. 6, 2004"Molecular Motors is an excellent source book that provides much-needed up-to-date introduction and an important snapshot of current knowledge of a rapidly expanding field of biology."Edgar Meyhofer, Department of mechanical Engineering, University of Michigan, Advanced Materials, September3, 2004"...a unique collection of chapters written by leaders who are well versed with the field...Overall, the book will be an excellent source for both professional and general readers, providing a wide range of in-depth insights into the structure, mechanism, function, and role of molecular motors in the life cycle of a cell."Quarterly Review of Biology, March-May 2005