Neighboring Group Participation
Volume 1 Withdrawn
(Sprache: Englisch)
Neighboring group participation is a term which encompasses all intra molecular reactions and all reactions which involve nonelectrostatic through-space interactions between groups within the same molecule. The term was invented in 1942 by Saul Winstein,...
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Klappentext zu „Neighboring Group Participation “
Neighboring group participation is a term which encompasses all intra molecular reactions and all reactions which involve nonelectrostatic through-space interactions between groups within the same molecule. The term was invented in 1942 by Saul Winstein, whose many contributions to the growth and maturing of the subject are unequaled. Although the inventor of the term, Winstein was not the first worker to study neighboring group participation. An examination of Beilstein will show that many intramolecular reactions were known to the synthetic organic chemist weIl before the turn ofthe century, and as early as 1891 W. P. Evans, working at Giessen, described a kinetic investigation of the base-promoted cycliza ti on of ethylene chlorohydrins to ethylene oxides-an important intra molecular reaction. He was followed some twenty years later by Freundlich, whose va1uab1e studies on participation by the amino group began to appear in 1911. Freundlich was later joined by Salomon, who by the mid-thirties had developed a reasonable understanding of the efficiency of the neigh boring amino group in acyclic systems. In the late twenties to mid-thirties the subject began to expand with the work of Bennett on participation by thioether groups, Nilsson and Smith on neighboring hydroxyl, and Caldin and Wolfenden on neighboring carboxylate, and with discussions of the dependence of cyclization rates on ring size by Ruzicka, Salomon, and Bennett.
Inhaltsverzeichnis zu „Neighboring Group Participation “
1. General Considerations.- 1. Introduction.- 1.1. Historical and General Description of Neighboring Group Effects.- 1.2. Terms and Definitions.- 2. Some Factors that Influence Anchimeric Assistance.- 2.1. The Stabilities of Bridged Carbocations-Some Molecular Orbital Calculations.- 2.2 Hyperconjugation-An Alternative Explanation?.- 2.3. The Effect of Intramolecularity-Ring Size and gew-Dialkyl Effects.- 2.3.1. Ring Size.- 2.3.2. The gem-Dialkyl Effect.- 3. Some Experimental Methods Used in the Study of Neighboring Group Participation.- 3.1. Kinetic Methods.- 3.1.1. Estimation of Reaction Rates.- 3.1.2. Participation as a Function of Electron Demand.- 3.1.3. Kinetic Isotope Effects.- 3.2. Investigation of Solvent Effects.- 3.3. Isolation or Trapping of Intermediates.- 3.4. Spectroscopic Observation of Intermediates.- 3.5. Product Analysis.- 2. Participation by Simple Oxygen, Sulfur, and Nitrogen Groups.- 4. Participation by Oxygen Groups.- 4.1. Ether Groups.- 4.1.1. In SolvolyticDisplacement Reactions.- 4.1.2. In Reactions at Carbonyl Carbon.- 4.1.3. In Electrophilic Addition Reactions.- 4.2. Hydroxyl Groups.- 4.2.1. In Solvolytic Displacement Reactions.- 4.2.2. In Addition Reactions.- 4.2.3. In Elimination Reactions.- 4.2.4. In Hydrolysis and Related Reactions.- 4.2.5. In Reduction Reactions.- 4.3. Hydroperoxide Groups.- 4.4. Oxime Groups.- 5. Participation by Sulfur Groups.- 5.1. Thioether Groups.- 5.1.1. In Solvolytic Displacement Reactions.- 5.1.2. In Electrophilic Addition Reactions.- 5.1.3. In Elimination Reactions.- 5.1.4. In Free-radical, Carbene, and Photochemical Reactions.- 5.2. Thiol Groups.- 6. Participation by Nitrogen Groups.- 6.1. Amino Groups.- 6.1.1. Anchimeric Assistance in Ring Closure Reactions.- 6.1.2. R2N-3 Participation.- 6.1.3. R2N-4 Participation.- 6.1.4. R2N-5 and R2N-6 Participation.- 6.1.5. Miscellaneous Modes of Participation.- 6.2. Nitrile Groups.- 6.3. Hydrazone Groups.- Author Index.
Bibliographische Angaben
- 2012, Softcover reprint of the original 1st ed. 1976., 280 Seiten, Maße: 22,9 cm, Kartoniert (TB), Englisch
- Herausgegeben von Capon, Brian
- Verlag: Springer
- ISBN-10: 1468408283
- ISBN-13: 9781468408287
Sprache:
Englisch
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