Nonviral Vectors for Gene Therapy
Methods and Protocols
(Sprache: Englisch)
The purpose of this volume of Methods in Molecular Medicine is to set forth examples of the great variety of techniques and applications that are now emerging in the field of nonviral gene therapy. The book emphasizes not only specific approaches to gene...
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Klappentext zu „Nonviral Vectors for Gene Therapy “
The purpose of this volume of Methods in Molecular Medicine is to set forth examples of the great variety of techniques and applications that are now emerging in the field of nonviral gene therapy. The book emphasizes not only specific approaches to gene delivery but, in particular, the best current me- ods to prepare, handle, and characterize gene delivery agents. These topics are of very broad importance since gene therapy evolves from its mostly ac- emy-based experimental and clinical research to the ever increasing number of industry-driven programs directed toward commercial development. S- cessful introduction of nonviral gene therapy agents into the clinic should be expected to require rigorous manufacturing and analytical methods that readily meet the regulatory guidelines under which new drug candidates are reviewed for marketing approval. Exactly what those guidelines will prove to be c- tainly depends on the established guidelines for review of both biological and chemical therapeutics. Additionally, many new techniques are being devised and applied to gene therapy research; these techniques will be instrumental in developing and characterizing successful gene delivery agents. Nonviral Vectors for Gene Therapy: Methods and Protocols has two main sections. To start with, there is a series of chapters on specific protocols for the synthesis, characterization, and application of gene delivery agents. S- eral chapters address the topic of materials to bind with DNA to form the compact condensed phases that facilitate cellular delivery.
Inhaltsverzeichnis zu „Nonviral Vectors for Gene Therapy “
- Synthesis of Polyampholyte Comb-Type Copolymers Consisting of a Poly(l-lysine) Backbone and Hyaluronic Acid Side Chains for DNA Carrier- Atsushi Maruyama and Yoshiyuki Takei
- Cationic _-Helical Peptides for Gene Delivery into Cells
- Takuro Niidome and Haruhiko Aoyagi
- Supramolecular Self-Assembly of Poly(ethylene glycol)-Block-Poly (l-lysine) Dendrimer with Plasmid DNA
- Joon Sig Choi and Jong Sang Park
- Water-Soluble Cationic Methacrylate Polymers for Nonviral Gene Delivery
- Gert W. Bos, Daan J. A. Crommelin, and Wim E. Hennink
- Stabilization of Polycation-DNA Complexes by Surface Modification with Hydrophilic Polymers
- David Oupicky, Martin L. Read, and Thierry Bettinger
- Use of Disulfide Cationic Lipids in Plasmid DNA Delivery
- Fuxing Tang and Jeffrey A. Hughes
- Interactions of Lipid-Oligonucleotide Conjugates with Low-Density Lipoprotein
- Erik T. Rump, Erik A. L. Biessen, Theo J. C. van Berkel, and Martin K. Bijsterbosch
- Coupling of Nuclear Localization Signals to Plasmid DNA
- Carole Neves, Daniel Scherman, and Pierre Wils
- Progress Toward a Synthetic Virus: A Multicomponent System for Liver-Directed DNA Delivery
- Bo-Hua Zhong, George Y. Wu, and Catherine H. Wu
- Characterization of Polyampholyte Comb-Type Copolymer DNA Carriers
- Yoshiyuki Takei, Atsushi Maruyama, Toshihiro Akaike, and Nobuhiro Sato
- Methods for Studying the Formation of Polycation-DNA Complexes and Properties Useful for Gene Delivery
- Martin L. Read, Thierry Bettinger, and David Oupicky
- Characterization of DNA Condensates by Atomic Force Microscopy
- Ye Fang and Jan H. Hoh
- Rapid and Systematic Transfer and Recovery of Large BACs/PACs into Mammalian Cells by HAEC Retrofitting
- Rona S. Scott and Jean-Michel H. Vos
- Systemic Delivery of Therapeutic Proteins by Intramuscular Injection of Plasmid DNA
- Holly M. Horton and Suezanne E. Parker
- Local Delivery of Therapeutic Proteins by Intratumoral Injection of Plasmid
... mehr
DNA-Lipid Complexes
- Holly M. Horton and Suezanne E. Parker
- Nonviral DNA Delivery from Polymeric Systems
- Lonnie D. Shea and David J. Mooney
- Promotion of Duplex and Triplex DNA Formation by Polycation Comb-Type Copolymers
- Hidetaka Torigoe and Atsushi Maruyama
- Lyophilization of Nonviral Gene Delivery Systems
- S. Dean Allison and Thomas J. Anchordoquy
- Ultraviolet Absorption and Circular Dichroism Spectroscopy of Nonviral Gene Delivery Complexes
- Chad S. Braun, Lisa A. Kueltzo, and C. Russell Middaugh
- Characterization of Synthetic Gene Delivery Vectors by Infrared Spectroscopy
- Sirirat Choosakoonkriang, Christopher M. Wiethoff, Lisa A. Kueltzo, and C. Russell Middaugh
- Characterization of Cationic Vector-Based Gene Delivery Vehicles Using Isothermal Titration and Differential Scanning Calorimetry
- Brian A. Lobo, Sheila A. Rogers, Christopher M. Wiethoff, Sirirat Choosakoonkriang, Susan Bogdanowich-Knipp, and C. Russell Middaugh
- Light-Scattering Techniques for Characterization of Synthetic Gene Therapy Vectors
- Christopher M. Wiethoff and C. Russell Middaugh
- Renal Gene Therapy
- Yeong-Hau H. Lien and Li-Wen Lai
- Holly M. Horton and Suezanne E. Parker
- Nonviral DNA Delivery from Polymeric Systems
- Lonnie D. Shea and David J. Mooney
- Promotion of Duplex and Triplex DNA Formation by Polycation Comb-Type Copolymers
- Hidetaka Torigoe and Atsushi Maruyama
- Lyophilization of Nonviral Gene Delivery Systems
- S. Dean Allison and Thomas J. Anchordoquy
- Ultraviolet Absorption and Circular Dichroism Spectroscopy of Nonviral Gene Delivery Complexes
- Chad S. Braun, Lisa A. Kueltzo, and C. Russell Middaugh
- Characterization of Synthetic Gene Delivery Vectors by Infrared Spectroscopy
- Sirirat Choosakoonkriang, Christopher M. Wiethoff, Lisa A. Kueltzo, and C. Russell Middaugh
- Characterization of Cationic Vector-Based Gene Delivery Vehicles Using Isothermal Titration and Differential Scanning Calorimetry
- Brian A. Lobo, Sheila A. Rogers, Christopher M. Wiethoff, Sirirat Choosakoonkriang, Susan Bogdanowich-Knipp, and C. Russell Middaugh
- Light-Scattering Techniques for Characterization of Synthetic Gene Therapy Vectors
- Christopher M. Wiethoff and C. Russell Middaugh
- Renal Gene Therapy
- Yeong-Hau H. Lien and Li-Wen Lai
... weniger
Bibliographische Angaben
- 2001, 416 Seiten, Maße: 15,7 x 23,5 cm, Gebunden, Englisch
- Herausgegeben: Mark A. Findeis
- Verlag: Humana Press
- ISBN-10: 0896037126
- ISBN-13: 9780896037120
- Erscheinungsdatum: 09.08.2001
Sprache:
Englisch
Rezension zu „Nonviral Vectors for Gene Therapy “
The book begins with a series of chapters covering specific protocols concerning gene delivery agents. These are followed by several review chapters that provide additional information on preparing and characterizing gene transfer agents. Particular focus is given to spectroscopic techniques. The final chapter provides a review of renal gene therapy. Chapters are well organized and often accompanied by helpful figures. Each chapter includes a list of references, an an index is provided. Contributors are from research facilities throughout the world. This book is highly recommended for collections serving researchers in the area of gene therapy. - E-Streams
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