Optogenetics
Tools for Controlling and Monitoring Neuronal Activity
(Sprache: Englisch)
Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by...
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Klappentext zu „Optogenetics “
Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology. These tools are already revolutionizing neuroscience, and are starting to have impact on fields ranging from metabolism to development to cardiology. The book contains a dozen chapters written by world experts on these topics, half focusing on the optogenetic molecular tools themselves, and half on the genetic and hardware approaches that make them powerfully useful in intact tissues and organisms.
Inhaltsverzeichnis zu „Optogenetics “
- A comprehensive concept of optogenetics
- Optogenetic excitation of neurons with channelrhodopsins: light instrumentation, expression systems, and channelrhodopsin variants
- Genetically encoded molecular tools for light-driven silencing of targeted neurons
- Genetically encoded probes for optical imaging of brain electrical activity
- Neural activity imaging with genetically encoded calcium indicators
- Manipulating cellular processes using optical control of protein-protein interactions
- Two-photon optogenetics
- Zebrafish as an appealing model for optogenetic studies
- Genetic targeting of specific neuronal cell types in the cerebral cortex
- Mouse transgenic approaches in optogenetics
- Optogenetics in the nonhuman primate
- Optogenetic Reporters: Fluorescent Protein-Based Genetically-Encoded Indicators of Signaling and Metabolism in the Brain Mathew Tantama, Yin Pun Hung,and Gary Yellen
Guillaume P. Dugué, Walther Akemann, and Thomas Knöpfel
John Y. Lin
Brian Y. Chow, Xue Han, and Edward S. Boyden
Amelie Perron, Walther Akemann, Hiroki Mutoh and Thomas Knöpfel
Lin Tian, Jasper Akerboom, Eric R. Schreiter, and Loren L. Looger
Chandra L. Tucker
Dan Oron, Eirini Papagiakoumou, F. Anselmi, and Valentina Emiliani
Joshua Simmich, Eric Staykov, and Ethan Scott
Alan Urban, and Jean Rossier
Hongkui Zeng, and Linda Madisen
Xue Han
Bibliographische Angaben
- Autor: Thomas Knopfel
- 2012, 288 Seiten, mit Abbildungen, Maße: 21,7 x 28,7 cm, Gebunden, Englisch
- Herausgegeben: Thomas Knopfel, Edward S. Boyden
- Verlag: Elsevier Science
- ISBN-10: 0444594264
- ISBN-13: 9780444594266
- Erscheinungsdatum: 22.05.2012
Sprache:
Englisch
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