Oral Delivery of Insulin

List of figures and tablesFiguresTables About the authors 1: Diabetes mellitus - an overviewAbstract1.1 Diabetes mellitus - an introduction1.2 Glucose homeostasis1.3 Types of diabetes1.4 Symptoms of diabetes1.5 Complications of diabetes1.6 Diagnosis of diabetes mellitus1.7 Therapy for diabetes1.8 Non-insulin treatment options of type 1 diabetes1.9 Treatment options of type 2 diabetes1.10 Conclusion 2: Routes of administration of insulinAbstract2.1 Current approach for the delivery of insulin2.2 Routes of administration of insulin2.3 Conclusion 3: Oral insulin delivery - challenges and strategiesAbstract3.1 Oral delivery of insulin3.2 Barriers to oral delivery of insulin3.3 Strategies and alternatives to improve oral insulin delivery3.4 Conclusion 4: Experimental techniques involved in the development of oral insulin carriersAbstract4.1 Introduction4.2 Polymeric nanoparticles4.3 Physicochemical characterization of nanoparticles4.4 Biologicalevaluation4.5 In vitro method for assessing drug permeability4.6 In vivo study of oral insulin4.7 Biodistribution studies4.8 Conclusion 5: Lipids and inorganic nanoparticles in oral insulin deliveryAbstract5.1 Lipid-based systems for oral delivery of insulin5.2 Liposomes5.3 Solid lipid nanoparticles5.4 Nanostructured lipid carriers5.5 Niosomes5.6 Archaeosomes5.7 Cubic nanoparticles (cubosomes)5.8 Aquasomes5.9 Inorganic nanoparticles as carriers for oral insulin delivery5.10 Conclusion 6: Polymers in oral insulin deliveryAbstract6.1 Introduction6.2 Characteristics of an ideal oral insulin carrier6.3 Polymers in oral insulin delivery6.4 Natural polymers6.5 Synthetic polymers6.6 Conclusion 7: Summary and future perspectives for oral insulin deliveryAbstract7.1 Introduction7.2 Technologies developed for clinical applications of oral insulin delivery7.3 Conclusions and future perspectives Index

T. A. Sonia is a doctoral student working in the field of development of polymeric nano/micro particles for oral delivery of insulin under the guidance of Dr Chandra P Sharma at Biosurface Technology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Science & Technology, Kerala, India. She completed her graduate studies in Polymer Science from School of Chemical Sciences, Mahatma Gandhi University, Kerala, India.