Pharmaceutical Biotechnology

1 Pharmaceuticals, Biologics and Biopharmaceuticals
 
1.1 Introduction to pharmaceutical products
 
1.2 Biopharmaceuticals and pharmaceutical biotechnology
 
1.3 History of the pharmaceutical industry
 
1.4 The age of biopharmaceuticals
 
1.5 Biopharmaceuticals: current status and future prospects
 
Further reading 2 Protein Structure
 
2.1 Introduction
 
2.2 Overview of protein structure
 
2.3 Higher level structure
 
2.4 Protein stability and folding
 
2.5 Protein post-translational modification
 
Further reading 3 Gene Manipulation and Recombinant DNA Technology
 
3.1 Introduction
 
3.2 Nucleic acids: function and structure
 
3.3 Recombinant production of therapeutic proteins
 
3.4 Classical gene cloning and identification
 
Further reading 4 The Drug Development Process
 
4.1 Introduction
 
4.2 Discovery of biopharmaceuticals
 
4.3 The impact of genomics and related technologies upon drug discovery
 
4.4 Gene chips
 
4.5 Proteomics
 
4.6 Structural genomics
 
4.7 Pharmacogenetics
 
4.8 Initial product characterization
 
4.9 Patenting
 
4.10 Delivery of biopharmaceuticals
 
4.11 Preclinical studies
 
4.12 Pharmacokinetics and pharmacodynamics
 
4.13 Toxicity studies
 
4.14 The role and remit of regulatory authorities
 
4.14 Conclusion
 
Further reading 5 Sources and Upstream Processing
 
5.1 Introduction
 
5.2 Sources of biopharmaceuticals
 
5.3 Upstream processing
 
Further reading 6 Downstream Processing
 
6.1 Introduction
 
6.2 Initial product recovery
 
6.3 Cell disruption
 
6.4 Removal of nucleic acid
 
6.5 Initial product concentration
 
6.6 Chromatographic purification
 
6.7 High-performance liquid chromatography of proteins
 
6.8 Purification of