Proteases in Health and Disease

Part A: Molecular and Biochemical Aspects of Proteases.- 1. An Overview of Endoplasmic Reticulum Calpain System.- 2. Mitochondrial Calpains: Who, What, Where, When and Why?.- 3. Role of Calpains in Calmodulin Regulated Systems.- 4. Exercise and Matrix Metalloproteases: A Brief Overview.- 5. Regulation of Chondrocyte Matrix Metalloproteinase Gene Expression.- 6. Microbial Source of Fibrinolytic Protease and Its Biotechnological Potential.- 7. Aspartic Proteolytic Inhibitors Induce Cellular and Biochemical Alterations in Fungal Cells.- 8. Cysteine Proteases of Human Malaria Parasites.- 9. Proteases as Virulence Factors in Leishmania: Focus on Serine Proteases as Possible Therapeutic Targets.- 10. An Updated Inventory on Properties, Pathophysiology and Therapeutic Potential of Snake Venom Thrombin-like Proteases.- 11. Macrocyclic Protease Inhibitors Constrained into a beta-Strand Geometry.- Part B: Involvement of Proteases in Disease Processes.- 12. Regulation of MT1-MMP Activation and Its Relevance to Disease Processes.- 13. Role of Proteases During Intra-erythrocytic Developmental Cycle of Human Malaria Parasite Plasmodium falciparum.- 14. Proteases in Vibrio cholerae and Their Role in Pathogenesis.- 15. ADAMTS13: The von Willebrand Factor Cleaving Protease and Its Role in Thrombotic Thrombocytopenic Purpura.- 16. Role of Proteases and Their Tissue Inhibitors in Pregnancy Outcome.- 17. Matrix Metalloproteinases in Bone Health and Disease.- 18. Escalated Expression of Matrix Metalloproteinases in Osteoarthritis.- 19. Role of Proteases in Autism Spectrum Disorder.- 20. Role of Proteases in the Management of Hepatitis C Virus.- 21. Role of Protease in Inflammatory Lung Diseases.- 22. Involvement of Some Proteolytic Enzymes in Cardiac Dysfunction Due to Ischemia-Reperfusion Injury.

Dr. Sajal Chakraborti is a Senior Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research covers the role of proteases in regulating pulmonary vascular tone under oxidant- and calcium-signaling phenomena. He has been engaged in teaching and research in biochemistry for the past 35 years.