Purely Peptidic Amphiphiles: Understanding and Controlling their Self-Assembled Structures
(Sprache: Englisch)
Amphiphilic molecules spontaneously self-assemble into a variety of structures in solution. The term amphiphilic indicates that one part of the molecule is attracted to the solvent, while the other is not. Interactions such as between solute-solvent and...
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Amphiphilic molecules spontaneously self-assemble into a variety of structures in solution. The term amphiphilic indicates that one part of the molecule is attracted to the solvent, while the other is not. Interactions such as between solute-solvent and solute-solute thus determine the organization. Understanding the self-assembly means understanding those interactions and their driving forces. In the first chapter an overview of the self-organization of amphiphilic molecules into supermolecuar aggregates of different morphologies is provided, with a focus on purely peptidic amphiphiles, i.e. amphiphiles which consist solely of a different amino acid sequence. In the second chapter the self-assembly of amphiphilic peptides with a specific amino acid sequence into micelles and spherical peptide nanoparticles is described. The undecamer peptide that was used features a repetitive L-tryptophan and D-leucine [LW-DL] motif, representing the hydrophobic block - which is a truncated version of gramicidin A (gA), named gT. The N-terminally attached hydrophilic section was either lysine (K) or acetylated lysine (X) and was optionally terminated with cysteine for post-functionalization of the thiol-group. The uncharged peptide AcC-X3-gT was demonstrated to assemble into micelles and subsequently into peptide particles, termed 'peptide beads'. We hypothesize that the peptide beads consisted of micelles - a structure described as multicompartment micelles. Peptide beads using AcC-X3-gT and its analogues - including Ac-X3-gT-C, a new peptide with the cysteine residue on the C instead of the N-terminus - are further investigated in Chapter Three. We succeeded in creating highly ordered Ac-X3-gT-C - Au-NP composites, which allowed us to visualize the inner structure of the nanoparticles. The presented composite materials are expected to exhibit exceptional electrical and optical properties.
Bibliographische Angaben
- Autor: Thomas Schuster
- 138 Seiten, Maße: 14,8 x 21 cm, Kartoniert (TB), Englisch
- Verlag: Cuvillier Verlag
- ISBN-10: 3869557974
- ISBN-13: 9783869557977
- Erscheinungsdatum: 05.07.2011
Sprache:
Englisch
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