Retrovirus Restriction in Primates and the Discovery of TRIMCyp
(Sprache: Englisch)
Cells derived from numerous primate species are known to resist HIV-1 infection, a finding that had limited the development of non-human primate models of AIDS. In recent years, several studies suggested that many primate-derived cell lines possess dominant...
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Cells derived from numerous primate species are known to resist HIV-1 infection, a finding that had limited the development of non-human primate models of AIDS. In recent years, several studies suggested that many primate-derived cell lines possess dominant factors that block infection by various retroviruses. In the work described here, one of these factors was identified as a protein named TRIM-Cyp. In addition to its potent ability to interfere with HIV infection, TRIM-Cyp also represents an important mechanism in the formation of new genes - it is a hybrid between two unrelated genes, created by the activity of a retrotransposon. TRIM-Cyp, and other TRIM5 proteins in various primates, are important determinants of retrovirus tropism, and reveal a great deal about the evolutionary arms race between retroviruses and their hosts.
Autoren-Porträt von David Sayah
David Sayah is currently a resident physician in San Francisco. The research described here was completed while he was a graduate student at Columbia University in New York City.
Bibliographische Angaben
- Autor: David Sayah
- 144 Seiten, Maße: 15 x 22 cm, Kartoniert (TB), Englisch
- Verlag: VDM Verlag Dr. Müller
- ISBN-10: 3836471078
- ISBN-13: 9783836471077
- Erscheinungsdatum: 06.12.2012
Sprache:
Englisch
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