RNA Interference
Challenges and Therapeutic Opportunities
(Sprache: Englisch)
RNA Interference: Challenges and Therapeutic Opportunities provides readers with recent advances in siRNA design, delivery, targeting and methods to minimize siRNA's unwanted effects. Preclinical and clinical use of synthetic siRNAs, the roles of miRNAs in...
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RNA Interference: Challenges and Therapeutic Opportunities provides readers with recent advances in siRNA design, delivery, targeting and methods to minimize siRNA's unwanted effects. Preclinical and clinical use of synthetic siRNAs, the roles of miRNAs in cancer and the promise of extracellular miRNAs for diagnosis are also covered in this meticulous collection, along with novel methods for identifying endogenous siRNAs and the annotation of small RNA transcriptomes. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Comprehensive and cutting-edge, RNA Interference: Challenges and Therapeutic Opportunities will aid researchers, clinicians, teachers and biotechnologists interested in the power of RNA-based therapies.
Inhaltsverzeichnis zu „RNA Interference “
1. RNA Interference: Mechanisms, Technical Challenges, and Therapeutic OpportunitiesMouldy Sioud
2. Nanostructured RNAs for RNA Interference
Yuko Nakashima, Naoko Abe, Yoshihiro Ito, and Hiroshi Abe
3. One Long Oligonucleotide or Two Short Oligonucleotides Based shRNA Construction and Expression
Xue-jun Wang and Sheng-qi Wang
4. PLGA Microspheres Encapsulating siRNA
Giuseppe De Rosa and Giuseppina Salzano
5. Magnetic Nanoparticle and Magnetic Field Assisted siRNA Delivery In Vitro
Olga Mykhaylyk, Yolanda Sanchez-Antequera, Dialechti Vlaskou, Maria Belen Cerda, Mehrdad Bokharaei, Edelburga Hammerschmid, Martina Anton, and Christian Plank
6. Cytoplasmic Delivery of siRNAs to Monocytes and Dendritic Cells Via Electroporation
Mouldy Sioud
7. Delivery of siRNAs to Cancer Cells Via Bacteria
Omar Ahmed, Andrea Krühn, and Hermann Lage
8. Microwell Array-Mediated Delivery of Lipoplexes Containing Nucleic Acids for Enhanced Therapeutic Efficacy
Yun Wu, Daniel Gallego-Perez, and L. James Lee
9. Modulating the Tumor Microenvironment with RNA Interference as a Cancer Treatment Strategy
Karin Zins, Mouldy Sioud, Seyedhossein Aharinejad, Trevor Lucas, and Dietmar Abraham
10. Targeted In Vivo Delivery of siRNA and an Endosome-Releasing Agent to Hepatocytes
Magdolna G. Sebestyén, So C. Wong, Vladimir Trubetskoy, David L. Lewis, and Christine I. Wooddell
11. Cell-Internalization SELEX: Method for Identifying Cell-Internalizing RNA Aptamers for Delivering siRNAs to Target Cells
William H. Thiel, Kristina W. Thiel, Katie S. Flenker, Tom Bair, Adam J. Dupuy, James O. McNamara II, Francis J. Miller, and Paloma H. Giangrande
12. Strategies for siRNA Navigation to Desired Cells
Mouldy Sioud
13. Analysis of RNA Interference-Mediated Hepatic Gene Silencing Following Murine
... mehr
Hydrodynamic Injection of Guanidinopropyl-Modified siRNAs
Maximilian C.R. Buffb, Stefan Bernhardt, Musa D. Marimani, Abdullah Ely, Joachim W. Engels, and Patrick Arbuthnot
14. Therapy of Respiratory Viral Infections with Intranasal siRNAs
Sailen Barik and Patrick Lu
15. Engineering Therapeutic Cancer Vaccines that Activate Anti-Tumor Immunity
Per Ole Iversen and Mouldy Sioud
16. Immunosuppressive Factor Blockade in Dendritic Cells Via siRNAs Results in Objective Clinical Responses
Mouldy Sioud, Anne Mobergslien, and Stein Sæbøe-Larssen
17. Targeting bcr-abl Transcripts with siRNAs in an Imatinib-Resistant Chronic Myeloid Leukemia Patient: Challenges and Future Directions
Michael Koldehoff
18. A Facile Method for Interfering with Off-Target Silencing Mediated by the Sense Strand
Anne Mobergslien and Mouldy Sioud
19. Overcoming the Challenges of siRNA Activation of Innate Immunity: Design Better Therapeutic siRNAs
Mouldy Sioud
20. Gene Silencing In Vitro and In Vivo Using Intronic MicroRNAs
Jia Han Deng, Peter Deng, Shi-Lung Lin, and Shao-Yao Ying
21. In Silico Identification of Novel Endo-siRNAs
Andrew Schuster, Grant W Hennig, Nicole Ortogero, Dickson Luong, and Wei Yan
22. Computer-Assisted Annotation of Small RNA Transcriptomes
Nicole Ortogero, Grant W. Hennig, Dickson Luong, and Wei Yan
23. miR-CATCH: MicroRNA Capture Affinity Technology
Sebastian Vencken, Tidi Hassan, Noel G. McElvaney, Stephen G.J. Smith, and Catherine M. Greene
24. Roles of MicroRNAs in Cancers and Development
Shigeru Takasaki
25. Targeting MicroRNAs to Withstand Cancer Metastasis
Valentina Profumo, Valentina Doldi, Paolo Gandellini, and Nadia Zaffaroni
26. Urinary MicroRNAs as a New Class of Non-Invasive Biomarkers in Oncology, Nephrology, and Cardiology
Hana Mlcochova, Renata Hezova, Albano C. Meli, and Ondrej Slaby
27. Magnetic Bead-Based Isolation of Exosomes
Morten P. Oksvold, Axel Neurauter, and Ketil W. Pedersen
28. Modified 2'-Ribose Small RNAs Function as Toll-Like Receptor-7/8 Antagonists
Mouldy Sioud
Maximilian C.R. Buffb, Stefan Bernhardt, Musa D. Marimani, Abdullah Ely, Joachim W. Engels, and Patrick Arbuthnot
14. Therapy of Respiratory Viral Infections with Intranasal siRNAs
Sailen Barik and Patrick Lu
15. Engineering Therapeutic Cancer Vaccines that Activate Anti-Tumor Immunity
Per Ole Iversen and Mouldy Sioud
16. Immunosuppressive Factor Blockade in Dendritic Cells Via siRNAs Results in Objective Clinical Responses
Mouldy Sioud, Anne Mobergslien, and Stein Sæbøe-Larssen
17. Targeting bcr-abl Transcripts with siRNAs in an Imatinib-Resistant Chronic Myeloid Leukemia Patient: Challenges and Future Directions
Michael Koldehoff
18. A Facile Method for Interfering with Off-Target Silencing Mediated by the Sense Strand
Anne Mobergslien and Mouldy Sioud
19. Overcoming the Challenges of siRNA Activation of Innate Immunity: Design Better Therapeutic siRNAs
Mouldy Sioud
20. Gene Silencing In Vitro and In Vivo Using Intronic MicroRNAs
Jia Han Deng, Peter Deng, Shi-Lung Lin, and Shao-Yao Ying
21. In Silico Identification of Novel Endo-siRNAs
Andrew Schuster, Grant W Hennig, Nicole Ortogero, Dickson Luong, and Wei Yan
22. Computer-Assisted Annotation of Small RNA Transcriptomes
Nicole Ortogero, Grant W. Hennig, Dickson Luong, and Wei Yan
23. miR-CATCH: MicroRNA Capture Affinity Technology
Sebastian Vencken, Tidi Hassan, Noel G. McElvaney, Stephen G.J. Smith, and Catherine M. Greene
24. Roles of MicroRNAs in Cancers and Development
Shigeru Takasaki
25. Targeting MicroRNAs to Withstand Cancer Metastasis
Valentina Profumo, Valentina Doldi, Paolo Gandellini, and Nadia Zaffaroni
26. Urinary MicroRNAs as a New Class of Non-Invasive Biomarkers in Oncology, Nephrology, and Cardiology
Hana Mlcochova, Renata Hezova, Albano C. Meli, and Ondrej Slaby
27. Magnetic Bead-Based Isolation of Exosomes
Morten P. Oksvold, Axel Neurauter, and Ketil W. Pedersen
28. Modified 2'-Ribose Small RNAs Function as Toll-Like Receptor-7/8 Antagonists
Mouldy Sioud
... weniger
Bibliographische Angaben
- 2014, 2015, XVI, 495 Seiten, 58 farbige Abbildungen, Maße: 18,3 x 26 cm, Gebunden, Englisch
- Herausgegeben: Mouldy Sioud
- Verlag: Springer, Berlin
- ISBN-10: 1493915371
- ISBN-13: 9781493915378
- Erscheinungsdatum: 15.10.2014
Sprache:
Englisch
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