Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy

Table of Contents

Preface

Part I. Sensitization via membrane-bound receptors

1. Sensitization of epithelial cancer cells with human monoclonal antibodies

Peter Vollmers and Stephanie Brandlein

2. Targeting the transferrin receptor to overcome resistance to anti-cancer agents

Tracy R. Daniels, Isabel I. Neacato, Gustavo Helguera, Manuel L. Penichet

3. Chemo-immunosensitization of resistant B-NHL as a result of rituximab (anti CD20 mAb)-mediated inhibition of cell survival signaling pathways

Benjamin Bonavida, Ali R. Jazirehi, Mario I. Vega, Sara Huerta-Yepez, Kazuo Umezawa, and Eriko Suzuki

4. Agents that regulate DR5 and sensitivity to TRAIL

Tatsushi Yoshida and Toshiyuki Sakai

5. Proteasome inhibition: Potential for sensitization of immune effector mechanisms in cancer

Milad Motarjemi, William H.D. Hallett, Minghui Li, and William J. Murphy

Part II. Sensitization via inhibition of cell survival pathways (excluding apoptotic signaling pathways)

6. Angiogenesis inhibitors as chemosensitizing agents for the treatment of metastatic disease

Giulio Francia, Urban Emmenegger, and Robert S. Kerbel.

7. Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK and P13K/Akt pathways to sensitize cancer cells to therapy

James A. McCubrey, Richard A. Franklin, Fred E. Bertrand, Jackson R. Taylor, illiam H. Chappell, Melissa L. Midgett, Ellis WT. Wong, Stephen L. Abrams, ristin M. Stadelman, Negin Misaghian, Dale E. Lugwid, Jorg Basecke, Massimo ibra, Franca Stivala, Michele Milella, Agostino Tafuri, Alberto M. Martelli, aolo Lungi, Antonio Bonati, David M. Terrian, Brian D. Lehmann, and Linda S. Steelman

8. Histone deacetylase inhibitors and anti-cancer activity

Roberto R. Rosato and Steven Grant

9. Eicosanoids and resistance of cancer cells to chemotherapeutic agents

Andrey Sorokin

Part III. Sensitization via transcription factors

10. The RKIP and STAT3 axis in cancer chemotherapy: opposites

From the reviews:"This book introduces emerging strategies, potential signaling pathways and biomolecules as key targets to sensitize resistant cancers. ... detailed information and data can be obtained from the references listed at the end of each chapter. This book helps chemists to enrich their biological insight, and biologists to acquire new chemical strategies in reversing cancer resistance. ... the book is also recommended to students in these fields. For scientists in industry and academia, and clinicians, this book provides an overview of current approaches ... ." (Yoshihiko Kotake, ChemMedChem, Vol. 4, 2009)