Signal Transducers and Activators of Transcription (STATs)

Foreword. Color Plates. 1. Introduction: a brief history of the STATs and a glance at the future; J.E. Darnell Jr. I: STAT Proteins and their Regulators. 2. The STAT protein family; M.H. Heim. 3. The Janus kinase protein family; P. Saharinen, O. Silvennoinen. 4. Structural bases of receptor-JAK-STAT interactions; P.C. Heinrich, et al. 5. SOCS proteins: negative regulators of the JAK/STAT pathway; R. Starr, D.J. Hilton. 6. The PIAS protein family and TC-PTP; Bin Liu, Ke Shuai. 7. Prime time for the Drosophila JAK/STAT pathway; E.A. Bach, N. Perrimon. 8. The STAT proteins of Dictyostelium; J.G. Williams. 9. JAK/STATs in zebrafish: conservation of JAK/STAT signaling in vertebrates; A.C. Oates, L.I. Zon. II: Mechanisms of Activation of and Transcriptional Regulation by STAT Proteins. 10. IFNs and STATs, an incestuous relationship; C. Schindler, Li Song. 11. Mechanisms and biological roles of STAT activation by the IL-6 family of cytokines; D. Kamimura, T. Hirano.12. Growth hormone induced activation and regulation of JAK2 and STAT proteins; J.H. Kurzer, C. Carter-Su. 13. G protein-coupled-receptor mediated STAT activation; J.M. Rodriguez-Frade, et al. 14. Regulation of STATs by posttranslational modifications; T. Decker, et al. 15. Interactions of STATs with SRC family kinases; C.M. Silva, et al. 16. The role of phosphatases and reactive oxygen species in regulation of the JAK/STAT pathway; A. Larner, M. David. 17. Raft-STAT signaling and transcytoplasmic trafficking; P.B. Seghal. 18. Nuclear trafficking of STAT proteins; K.M. McBride, N. Reich. 19. Interaction of STAT signals with other signaling pathways; D.R. Wesemann, G.M. Fuller. 20. Forward genetics in mammalian cells; E.S. Kandel, G.R. Stark. 21. X-ray crystal structure of STAT proteins and structure-activity relationships; C.W. Müller, et al. 22. STAT transcriptional activation mechanisms: communication with the basal transcriptional machinery; D.E. Levy. 23. STST-dependent gene expression without tyrosine