Sodium Calcium Exchange: A Growing Spectrum

Part I. Historical Perspective.- 1. Livin with NCX and Lovin It: 45 Year Romance.- 2. 20 Years from NCX Purification and Cloning: Milestones.- Part II Structural and Functional Aspects of NCX.- 3. Ca2+ Regulation in the Na+/Ca2+ Exchanger Features a Dual Electrostatic Switch Mechanism.- 4. Molecular Determinants of Allosteric Regulation in NCX Proteins.- 5. NCX1: Mechanism of Transport.- 6. Structural Studies of the Ca2+ Regulatory Domain of Drosophila Na+/Ca2+ Exchanger CALX.- 7. Interplay of Ca2+ and Mg2+ in Sodium-Calcium and in other Ca2+ Binding Proteins. Magnesium: Watchdog That Blocks Each Turn If Able.- Part III. Structural and Functional Aspects of NCKX.- 8. Functional and Structural Properties of the NCKX2 Na+-Ca2+/K+ Exchanger: a Comparison with the NCX1 Na+/Ca2+ Exchanger.- 9. NCKX5, a Natural Regulator of Human Skin Colour Variation Regulates the Expression of Key Pigment Genes mc1r and alpha-MSH, and Alters Cholesterol Homeostasis in Normal Human Melanocytes.- 10. Expression and Regulation of Sodium/Calcium Exchangers, NCX and NCKX, in Reproductive Tissues: Do They Play a Critical Role in Calcium Transport for Reproduction and Development?.- Part IV. Genetic and Epigenetic Regulation.- 11. Transcriptional Pathways and Potential Therapeutic Targets in the Regulation of NCX1 Expression in Cardiac Hypertrophy and Failure.- 12. Transcriptional Regulation of ncx1 Gene in the Brain.- Part V. Regulatory Mechanisms of NCX.- 13. Metabolic Regulation of the Squid Nerve Na+/Ca2+ Exchanger: Recent Developments.- 14. Regulation of Sodium-Calcium Exchanger Activity by Creatine Kinase.- 15. Coordinated Regulation of Cardiac Na

Lucio Annunziato is Professor of Pharmacology and chairman of the Department of Neuroscience in the School of Medicine at the "Federico II" University of Naples, Italy. He is coordinator of the University's Neuroscience Ph.D. program. He is also past-president of the Italian Society for Neuroscience. Dr. Annunziato has authored more that 190 full papers in peer reviewed international journals in the field of neuroscience and molecular pharmacology of plasmamembrane transporters and ionic channels involved in the pathophysiology of stroke and other neurodegenerative diseases. 

From the reviews:"It collects in one place state-of-the-art information on all facets of the structure and function of sodium calcium exchangers in biological systems with a special focus on pathophysiological implications. ... This will be of most value to research scientists, including students, whose research involves studying the mechanisms for maintaining ion homeostasis in biological systems. ... I highly recommend it to all researchers who work in the field of ion homeostasis." (Thomas L. Pazdernik, Doody's Book Reviews, March, 2013)