Systems Theory in Immunology

I. Antigenic Stimulation.- Mechanism of B Lymphocyte Activation.- Clonal Dominance: Presentation of Antigenic Subsites is the Determining Factor.- Hierarchic Immunogenicity of Protein Determinants.- Control of B Lymphocyte Activation through Reversible Binding of Multivalent Antigen: a Simple Model.- II. Cell Interactions.- Some Cellular Interactions Involved in the Primary Immune Response.- Some Models for the Interaction between Cells of the Immune Systems.- Stimulation of Memory Cells and Abrogation of Suppression with a Mobile Antigen - laden Cell.- Involvement of the Fc Receptor in Immune Regulation: a Hypothesis.- III. Evaluation and Evolution of Antibody Production.- Problems in the Evaluation of Antibody Affinity Distribution during the Immune Response.- Biological Variations of IgM Antibody Affinity.- Speculations on some Fundamental Aspects of the Regulation of the Quantity and Affinity of Antibody Produced during an Immune Response.- IV. Mathematical Modeling in Immunology.- Deterministic and Stochastic Bounded Rate Models in Immunology.- Some Basic Properties of Stochastic Population Models.- Systems Compartmentation in Immunological Modeling.- A Mathematical Model of the "Two Signal" Theory for T-B Cells Cooperation.- V. The Network Approach.- Idiotypic Regulation and H2 Restriction.- Immunoglobulin Gene Suppression and Expression.- Complexity and Regulation of the Immune System: the Network Approach.- The Stability of the Immune Network.- A Mathematical Model of the Stable States of a Network Theory of Self-Regulation.- Approaches for Data Reduction in Biological Networks.