TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease

1 Introduction: How we encountered TCTP and our purpose in studying it.- 2 Structural insights into TCTP and its interactions with ligands and proteins.- 3 Structure-Function relationship of TCTP.- 4 The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation.- 5 Current understanding of the TCTP interactome.- 6 Role and fate of TCTP in protein degradative pathways.- 7 Roles of the Translationally Controlled Tumor Protein (TCTP) in plant development.- 8 Function of Translationally controlled tumor protein in organ growth: Lessons from Drosophila studies.- 9 Translationally controlled tumor protein (TCTP/HRF) present in animal venoms.- 10 Tctp in Neuronal Circuitry Assembly.- 11 Elusive role of TCTP protein and mRNA in cell cycle and cytoskeleton regulation.- 12 TCTP protein and the cellular response to ionizing radiation-induced DNA damage.- 13 TCTP has a crucial role in the different stages of Prostate Cancer malignant progression.- 14 Role of TCTP for cellular differentiation and cancer therapy.- 15 Targeting TCTP with sertraline and thioridazine in cancer treatment.- 16 . History of Histamine Releasing Factor (HRF)/TCTP including a Potential Therapeutic Target in Asthma and Allergy.