Technological and Medical Implications of Metabolic Control Analysis
(Sprache: Englisch)
Two decades have passed since the mechanisms of protein synthesis became well enough understood to permit the genetic modification oforganisms. An impressive amount of new knowledge has emerged from the new technology, but much ofthe promise of20years ago...
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Two decades have passed since the mechanisms of protein synthesis became well enough understood to permit the genetic modification oforganisms. An impressive amount of new knowledge has emerged from the new technology, but much ofthe promise of20years ago has notyet been fulfilled. In biotechnology, efforts to increase the yields of commercially valuable metabolites have been less successful than ex pected, and when they have succeeded it has often been as much from selective breeding as from new methods. The cell is more complicated than what is presented in the classical teaching of biochemistry, it contains more structure than was dreamed of 20 years ago, and the behaviour ofany systemofenzymes is more elaborate than can be explained in terms ofa single supposedly rate-limiting enzyme. Even if classical enzymology and meta bolism may have seemed rather unfashionable during the rise ofmolecular biology, they remain central to any modification ofthe metabolic behaviour oforganisms. As such modification is essential in much ofbiotechnology and drug development, bio technologists can only ignore these topics at their peril.
The study of multienzyme systems has advanced considerably during the least decade. The cell is more complicated than classical biochemistry presents it, it contains more structure, and the behaviour of any system of enzymes is more elaborate than can be explained in simple terms. Nevertheless, classical enzymology and metabolism remain central to any modification of the metabolic behaviour of organisms, as attempted by modern biotechnology and drug development techniques. In this cool, objective look at the current state of the art, internationally respected authors draw attention to the drawbacks, problems, and opportunities associated with this exciting field. The areas covered include problems with current practice, the imposition of human objectives on organisms, understanding health and disease, computer modelling, the increasingly complex picture of cell structure, control and regulation of metabolism, and the general contribution metabolic control is making to biochemistry on a broader canvas.
Inhaltsverzeichnis zu „Technological and Medical Implications of Metabolic Control Analysis “
Preface. 1. Provoking an Argument: Problems with Current Approaches to the Analysis of Biochemical Systems. 2. Imposing Discipline: Manipulation of Organisms for Technological Ends. 3. Understanding Health and Disease: Why Organisms Behave as they do. 4. Taking Aim: Use of Metabolic Models to identify Drug Targets. 5. Facing Reality: Not just a Bag of Enzymes. 6. Thinking about Metabolism: The Relationship Between Control and Regulation. 7. Taking Stock: Control Analysis in the Context of Metabolic Regulation. Contributors. Index.
Bibliographische Angaben
- 2000, 392 Seiten, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Maria Luz Cárdenas, Athel Cornish-Bowden
- Verlag: Springer Netherlands
- ISBN-10: 0792361881
- ISBN-13: 9780792361886
- Erscheinungsdatum: 29.02.2000
Sprache:
Englisch
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