The Parvoviruses

1 Adeno-Associated Virus DNA Structure and Replication.- I. AAV DNA Structure.- II. Replication of AAV.- III. A Model for AAV DNA Replication.- IV. Host and Viral Proteins Required for AAV DNA Replication.- V. Conclusion.- References.- 2 Biology of Adeno-Associated Virus.- I. Introduction.- II. Association with Adenovirus.- III. Host Range.- IV. Experimental Infection in Utero.- V. Latent Infection.- VI. Inhibition of Adenovirus Oncogenicity.- VII. Interactions with Herpesviruses.- References.- 3 Adeno-Associated Virus Defectiveness and the Nature of the Adenovirus Helper Function.- I. Introduction.- II. Biological Background.- III. Definition of the Helper Function.- IV. Genome Structure and Growth Cycle of AAV.- V. Genome Structure and Growth Cycle of Adenovirus.- VI. Role of Specific Adenovirus Genes in AAV Helper Function.- VII. Growth of AAV in Transformed Cells and Inhibition of Adenovirus Functions.- VIII. Summary.- References.- 4 Autonomous Parvovirus DNA Structure and Replication.- I. DNA Structure.- II. DNA Replication.- III. Model for DNA Replication.- References.- 5 Parvovirus Transcription.- I. Introduction.- II. Methods for Study of Transcription.- III. RNA Synthesis and the Virus Growth Cycle.- IV. DNA Genome Orientation and RNA Strand Specificity.- V. In Vivo Transcription. RNA Structure and Genome Location.- VI. In Vitro Synthesis of Parvovirus RNA.- VII. Promoter Structures.- VIII. Post-transcriptional Modification.- IX. Control of RNA Abundance.- X. Coding Potential of Parvovirus mRNA.- XI. Summary.- References.- 6 Variant and Defective Interfering Parvoviruses.- I. Introduction.- II. Nomenclature.- III. Detection of Variant Parvoviruses.- IV. Physical Properties of Variant Particles.- V. Physical Structure of Variant DNA.- VI. In Vitro Construction of Variant Genomes.- VII. In Vivo Generation and Replication of Variants.- VIII. Interfering Properties of Variants.- IX. Mechanism of Interference.- X. Biological Inferences.- References.- 7