The Physiological Genomics of the Critically Ill Mouse

Content.- Section I: Physiological Monitoring of the Mouse 1.- Assessment of quality in commercially supplied genetically modified animals.- Cannulation techniques for multiple blood withdrawal in mice.- Mouse anesthesia in relation to optimal hemodynamics.- Mechanical ventilation of mice.- Mouse echocardiography.- ptical Spectroscopy in mice.- ECG monitoring and analyses in mice.- High-definition magnetic resonance of genetically modified mice.- Pet studies in the mouse.- Mouse telemetry for long-term monitoring.- Section II: Cardiovascular Pathophysiology of the Mouse 143.- Physiological genomics of reperfusion injury.- INOS-deficient mice in the study of resuscitated sepsis.- The microcirulation in hypercholesterolemic mice.- The mouse in shock.- Expression systems to analyze transgenes in the heart.- Structural and functional adaptations of the heart after coronary artery ligation in the Mouse.- Mouse models of sepsis.- Mouse models for arterial thrombosis: does clotting makea difference in human cardiovascular disease?.- Identification of mouse models of cardiovascular disease using mutagenesis.- Acute lung injury and pneumonia in mice.- Section III: Treating the Critically Ill Mouse 289.- Endothelial nitric oxide synthase in cardiovascular homeostasis and disease.- Arteriogenesis in mice.- Mouse models to study pro-and anti-angiogenic potential: novel roles for PIGF and Flt1.- Stem cell therapy in the mouse heart.- Gene therapy for the critically ill mouse.