The Relationship between Myeloperoxidase, Leukotriens & Paraoxonase

Preeclampsia (PE) is a disorder peculiar to pregnancy and a major cause of maternal death. It is associated with fetal growth restriction, low birth weight, preterm delivery and respiratory distress syndrome. Although the exact pathophysiological mechanisms of PE remain elusive. Studies to date have implicated multiple processes, including abnormal trophoblastic invasion, vasospasm, platelet activation, changes in the relative amounts of prostaglandins, activation of lipid peroxides, and imbalance in the vasomotor-regulating factors. Besides cytokines are important compounds implicated in the diffuse endothelial cell damage and neutrophil activation. The aim of this study was to assess the level of myeloperoxidase, paraoxonase, leukotriene B4 and leukotriene D4 and determine their role in prediction and management of PE and its severity. The conclusion of the study was that the significant changes in the serum concentrations of MPO, LTB4, LTD4 and PON in PE at different gestational periods can be used in the prediction of the PE and in diagnosis of disease severity