Transforming Growth Factor-Beta in Cancer Therapy, Volume I

- Component Hardware for Transforming Growth Factor-ß Signal Transduction: TGF-ß Ligands, TGF-ß Receptors, and Smads
- TGF-ß Signaling in Homeostasis and Cancer
- TGF-ß Availability: Latent TGF-ß and Latent TGF-ß Binding Proteins
- Biological Functions of Latent TGF-ß Binding Proteins and Activation of TGF-ß
- Regulators of Smad2/3 Transcription and Phosphorylation
- Interaction of Smad4 and Embryonic Liver Fodrin (ELF)-ß-spectrin in Hyperplasia, Neoplasia, and Tumor Progression
- Regulation of Smad Activity by Phosphorylation
- Nuclear Targeting of TGF-ß-activated Smads in Normal and Tumor Biology
- Ski, Sno and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival
- Smurfs in TGF-ß Signaling and Regulation of Bone Homeostasis and Cancer
- Involvement of KM23 Dynein Light Chains in TGF-ß Signaling
- TGF-ß Signaling in Fibroblastic Cells and Oncogenes
- Mechanisms of TGF-ß-induced Apoptosis in Cancer Cells
- Mechanisms of Cell Cycle Regulation by TGF-ß Disabled in Cancer
- Proteasome in the Control of TGF-ß Signaling During Development and Cancer
- TGF-ß and Smad Signaling in Transcriptome Reprogramming During Epithelial to Mesenchymal Transition
- Functional Interaction between MMPs and TGF-ß in Normal and Tumor Tissue
- Cooperation Between TGF-ß and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function
- Interaction of Oncogenic Ras and TGF-ß1 Signaling in Cancer: Lessons from the Multistage Skin Carcinogenesis Model
- Proteomics Analysis of TGFß Superfamily Members
- Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain Human Cancers
- Activins, Inhibins and Bone Morphogenetic Proteins as Modulators of Prostate Cancer Progression
- Bone Morphogenic Proteins and Angiogenesis in Developing Tumors
- Histone Methyltransferase and Smad Interactions in BMP Signaling
- Endoglin (CD105): A Strong Candidate for Immunologic Targeting of Tumor Neovasculature

From the reviews:"This volume provides a comprehensive review of TGF-beta regulation, signaling, and cellular function in both normal and tumor biology. ... will be of use to individuals interested in the role of TGF-beta in the development of cancer and fibrosis. This will likely benefit readers interested in TGF-beta in the pathogenesis of disease ... . also be a resource for those interested in the complex intracellular signaling cascades elicited by TGF-beta in normal and altered cells." (James P Luyendyk, Doody's Review Service, May, 2008)