UPF1
(Sprache: Englisch)
High Quality Content by WIKIPEDIA articles! Regulator of nonsense transcripts 1 is a protein that in humans is encoded by the UPF1 gene. This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in...
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High Quality Content by WIKIPEDIA articles! Regulator of nonsense transcripts 1 is a protein that in humans is encoded by the UPF1 gene. This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
Bibliographische Angaben
- 2010, 128 Seiten, Kartoniert (TB), Englisch
- Herausgegeben von Surhone, Lambert M.; Tennoe, Mariam T.; Henssonow, Susan F.
- Verlag: Betascript Publishing
- ISBN-10: 6131359458
- ISBN-13: 9786131359453
Sprache:
Englisch
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