A Handbook of Mouse Models of Cardiovascular Disease (PDF)

The availability of well-defined genetic strains and the ability to
create transgenic and knockout mice makes mouse models extremely
valuable biomedical tools. Their suitability as an experimental
system for cardiovascular research depends on the individual
investigator's ability to manipulate the mice surgically.
Many mouse models require microsurgical techniques, which hitherto
could not be performed without practical training. This
comprehensive handbook enables scientists to develop these models
in their own laboratories.

A Handbook of Mouse Models of Cardiovascular
Disease is the first book to address pathology in
mouse models of heart disease, providing the reader with essential
information on technical assays in artificially created models. It
includes background information on individual cardiovascular
diseases, describes detailed methods and materials used for
establishing each mouse model, discusses the problems that may
appear in the experiments, and provides examples of applications of
the model.

A Handbook of Mouse Models of Cardiovascular
Disease:

* Describes mouse models of all important cardiovascular
diseases, including atherosclerosis, atrial fibrillation and
thrombosis

* Features videos of key experimental procedures on the
accompanying CD, allowing researchers to learn the techniques by
directly watching the whole operational procedure

* Describes how to establish each experimental model with
detailed protocols and tips on dealing with common operational
problems

* Highlights potential applications of each model in areas such
as pathogenesis, gene transfer, therapy and
pathophysiology

This handbook is an invaluable resource for researchers in
cardiovascular disease, pathology, physiology, interested in the
mechanism of vascular disorders and therapeutic approaches. It is
also relevant to clinicians seeking to understand the pathology of
cardiovascular disease and the rationale for interventions, and of
interest to the pharmaceutical industry and all those involved in
drug discovery/development for cardiovascular disease.